Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Int J Rheum Dis. 2020 Nov;23(11):1452-1459. doi: 10.1111/1756-185X.13920. Epub 2020 Jul 27.
To investigate the relationship between ankylosing spondylitis (AS) and risk of dementia.
Potentially eligible studies that compared the risk of developing dementia between patients with AS and individuals without AS were identified from MEDLINE and EMBASE databases from inception to May 2019 using a search strategy that comprised terms for "dementia" and "ankylosing spondylitis". Eligible studies could be either cohort studies or case-control studies. For cohort design, eligible studies included patients with AS and comparators without AS and followed them for incident dementia. For case-control design, eligible studies included cases with dementia and controls without dementia and explored prior history of AS in both groups. Effect estimate and standard error from each study were extracted and combined together using the random effect, generic inverse variance. Funnel plot was used to assess for publication bias.
A total of 7091 articles were identified using the aforementioned search strategy. After 2 rounds of independent review by 3 investigators, 4 studies fulfilled the inclusion criteria and were included into the meta-analysis. The risk of developing dementia was significantly higher among patients with AS than individuals without AS with the pooled relative risk of 1.19 (95% CI 1.01-1.41; I = 76%). The funnel plot was relatively symmetric and was not suggestive of presence of publication bias.
A significantly 1.2 fold higher risk of developing dementia among patients with AS was demonstrated by this systematic review and meta-analysis.
探讨强直性脊柱炎（AS）与痴呆风险的关系。
通过检索 MEDLINE 和 EMBASE 数据库，从建库至 2019 年 5 月，采用包含“痴呆”和“强直性脊柱炎”的检索策略，以识别比较 AS 患者和无 AS 个体痴呆发病风险的潜在合格研究。合格研究可以是队列研究或病例对照研究。对于队列设计，合格研究包括 AS 患者和无 AS 对照者，并对其进行痴呆发病的随访。对于病例对照设计，合格研究包括痴呆病例和无痴呆对照者，并在两组中探索 AS 的既往史。从每项研究中提取效应估计值和标准误差，并使用随机效应、通用倒数方差法进行合并。采用漏斗图评估发表偏倚。
使用上述检索策略共确定了 7091 篇文章。经过 3 名研究者的两轮独立审查，有 4 项研究符合纳入标准并纳入荟萃分析。与无 AS 个体相比，AS 患者发生痴呆的风险显著更高，合并相对风险为 1.19（95%CI 1.01-1.41；I²=76%）。漏斗图相对对称，不提示存在发表偏倚。
本系统评价和荟萃分析表明，AS 患者发生痴呆的风险显著增加 1.2 倍。
