Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Lung. 2021 Jun;199(3):273-280. doi: 10.1007/s00408-021-00444-8. Epub 2021 May 13.
This study aimed to investigate the association between asthma and risk of myasthenia gravis (MG) using the method of systematic review and meta-analysis.
Potentially eligible studies were identified from Medline and EMBASE databases from inception to July 2020 using search strategy that comprised terms for "Asthma" and "Myasthenia Gravis". Eligible cohort study must consist of one cohort of individuals with asthma and another cohort of individuals without asthma. Then, the study must report relative risk (RR) with 95% confidence intervals (95% CIs) of incident MG between the groups. Eligible case-control studies must include cases with MG and controls without MG. Then, the study must explore their history of asthma. Odds ratio (OR) with 95% CIs of the association between asthma status and MG must be reported. Point estimates with standard errors were retrieved from each study and were combined together using the generic inverse variance method.
A total of 6,835 articles were identified. After two rounds of independent review by five investigators, two cohort studies and three case-control studies met the eligibility criteria and were included into the meta-analysis. Pooled analysis showed that asthma was significantly associated with risk of MG with the pooled risk ratio of 1.38 (95% CI 1.02-1.86). Funnel plot was symmetric, which was not suggestive of publication bias.
The current study found a significant association between asthma and increased risk of MG.
本研究旨在通过系统评价和荟萃分析的方法，探讨哮喘与重症肌无力（MG）风险之间的关联。
从 Medline 和 EMBASE 数据库中检索从建库至 2020 年 7 月的潜在合格研究，检索策略包括“哮喘”和“重症肌无力”的术语。合格的队列研究必须包含一组哮喘患者和另一组无哮喘患者。然后，该研究必须报告两组之间新发 MG 的相对风险（RR）及其 95%置信区间（95%CI）。合格的病例对照研究必须包括 MG 病例和无 MG 对照。然后，该研究必须探讨他们的哮喘病史。必须报告哮喘状况与 MG 之间关联的比值比（OR）及其 95%CI。从每项研究中检索点估计值及其标准误差，并使用通用倒数方差法将其合并在一起。
共确定了 6835 篇文章。经过五位研究人员两轮独立审查，两项队列研究和三项病例对照研究符合纳入标准并纳入荟萃分析。汇总分析表明，哮喘与 MG 风险显著相关，合并 RR 为 1.38（95%CI 1.02-1.86）。漏斗图对称，提示无发表偏倚。
本研究发现哮喘与 MG 风险增加之间存在显著关联。
