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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Calam J, Unwin R J, Dorudi S, Taylor C, Springer C J, Peart W S

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.

Clin Exp Pharmacol Physiol. 1988 Jun;15(6):491-5. doi: 10.1111/j.1440-1681.1988.tb01105.x.

The effect of intravenous vasoactive intestinal peptide (VIP, 6 pmol/kg per min) on renal function in six patients with cirrhosis of the liver was examined. 2. VIP caused generalized vasodilation and increased plasma renin activity, but diminished the glomerular filtration rate by about one third. 3. The excretion of water, sodium, potassium and calcium also fell significantly. 4. These results differ from our findings in normal man in whom VIP diminished water and electrolyte secretion largely by increasing tubular reabsorption. 5. It is concluded that the elevated VIP levels present in patients with severe liver disease may affect renal function, but that the presence of liver disease may affect renal responses to VIP.

研究了静脉注射血管活性肠肽（VIP，每分钟6 pmol/kg）对6例肝硬化患者肾功能的影响。2. VIP引起全身血管舒张并增加血浆肾素活性，但使肾小球滤过率降低约三分之一。3. 水、钠、钾和钙的排泄也显著减少。4. 这些结果与我们在正常人中的发现不同，在正常人中VIP主要通过增加肾小管重吸收来减少水和电解质分泌。5. 得出的结论是，严重肝病患者体内升高的VIP水平可能影响肾功能，但肝病的存在可能影响肾脏对VIP的反应。

Calam J, Unwin R J, Dorudi S, Taylor C, Springer C J, Peart W S

Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, England.

Clin Exp Pharmacol Physiol. 1988 Jun;15(6):491-5. doi: 10.1111/j.1440-1681.1988.tb01105.x.

The effect of intravenous vasoactive intestinal peptide (VIP, 6 pmol/kg per min) on renal function in six patients with cirrhosis of the liver was examined. 2. VIP caused generalized vasodilation and increased plasma renin activity, but diminished the glomerular filtration rate by about one third. 3. The excretion of water, sodium, potassium and calcium also fell significantly. 4. These results differ from our findings in normal man in whom VIP diminished water and electrolyte secretion largely by increasing tubular reabsorption. 5. It is concluded that the elevated VIP levels present in patients with severe liver disease may affect renal function, but that the presence of liver disease may affect renal responses to VIP.

研究了静脉注射血管活性肠肽（VIP，每分钟6 pmol/kg）对6例肝硬化患者肾功能的影响。2. VIP引起全身血管舒张并增加血浆肾素活性，但使肾小球滤过率降低约三分之一。3. 水、钠、钾和钙的排泄也显著减少。4. 这些结果与我们在正常人中的发现不同，在正常人中VIP主要通过增加肾小管重吸收来减少水和电解质分泌。5. 得出的结论是，严重肝病患者体内升高的VIP水平可能影响肾功能，但肝病的存在可能影响肾脏对VIP的反应。