Dimaline R, Peart W S, Unwin R J
J Physiol. 1983 Nov;344:379-88. doi: 10.1113/jphysiol.1983.sp014946.
Conscious rabbits received either vasoactive intestinal polypeptide (VIP) at a dose of 1, 10 or 25 pmol kg-1 min-1 or vehicle alone (control) through an ear vein for 2 h. Experimental design followed a randomized Latin square arrangement. VIP led to a decrease in effective renal plasma flow and glomerular filtration rate (P less than 0.01) during infusion of the middle and high doses. Mean arterial blood pressure rose slightly (P less than 0.05) and filtration fraction increased (P less than 0.01) during infusion of the middle dose. The high dose produced a rise in heart rate, a fall in plasma sodium, potassium and phosphate concentrations and a rise in plasma solids (P less than 0.01). In spite of the renal haemodynamic effects and changes in plasma composition during infusion of the high dose, fractional excretion of sodium, potassium and chloride doubled (P less than 0.05), suggesting a direct action of VIP on renal tubular function. Plasma renin activity increased between 2- and 3-fold (P less than 0.01). The mechanism of the renin response is uncertain. These results, together with the reported presence of VIP-like material in the renal cortex, may indicate a role for VIP in the regulation of renal function, including renin release.
清醒家兔通过耳静脉接受剂量为1、10或25 pmol kg-1 min-1的血管活性肠肽（VIP）或仅接受赋形剂（对照），持续2小时。实验设计采用随机拉丁方排列。在输注中、高剂量VIP期间，有效肾血浆流量和肾小球滤过率降低（P<0.01）。在输注中剂量VIP期间，平均动脉血压略有升高（P<0.05），滤过分数增加（P<0.01）。高剂量导致心率升高、血浆钠、钾和磷酸盐浓度降低以及血浆固体含量升高（P<0.01）。尽管在输注高剂量VIP期间有肾脏血流动力学效应和血浆成分变化，但钠、钾和氯分数排泄增加了一倍（P<0.05），提示VIP对肾小管功能有直接作用。血浆肾素活性增加了2至3倍（P<0.01）。肾素反应的机制尚不确定。这些结果，连同肾皮质中存在VIP样物质的报道，可能表明VIP在包括肾素释放在内的肾功能调节中起作用。
