短程化疗对唾液中对乙酰氨基酚消除的影响。
Effect of short course chemotherapy on salivary paracetamol elimination.
作者信息
Madhusudanarao K, Bapna J S, Adithan C, Ray K, Venkatadri N, Kamatchi G L, Seetharaman M L, Bahadur P
机构信息
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
出版信息
Clin Exp Pharmacol Physiol. 1988 Aug;15(8):639-43. doi: 10.1111/j.1440-1681.1988.tb01122.x.
Abstract
- Salivary elimination of paracetamol was studied in six male pulmonary tuberculosis patients on short course chemotherapy. 2. Peak paracetamol concentration showed a steady decrease at the end of first week and continued until the end of the study. 3. The elimination half-life of paracetamol decreased 5 weeks after the therapy with a corresponding increase in the clearance rate. 4. Adjustment of dosage of drugs that are metabolized by the microsomal enzymes may be required in patients on anti-tubercular drug regimen in which rifampicin is included.
摘要
- 对6名接受短程化疗的男性肺结核患者进行了对乙酰氨基酚唾液清除情况的研究。2. 对乙酰氨基酚的峰值浓度在第一周结束时呈稳定下降，并持续至研究结束。3. 治疗5周后对乙酰氨基酚的消除半衰期缩短，清除率相应增加。4. 对于接受包含利福平的抗结核药物治疗方案的患者，可能需要调整由微粒体酶代谢的药物剂量。
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