短期外科手术对唾液中扑热息痛消除的影响。
Effect of short surgical procedures on salivary paracetamol elimination.
作者信息
Ray K, Adithan C, Bapna J S, Kangle P R, Ray K, Ramakrishnan S
出版信息
Br J Clin Pharmacol. 1985 Aug;20(2):174-6. doi: 10.1111/j.1365-2125.1985.tb05054.x.
Abstract
The effect of short surgical procedures on paracetamol elimination was studied in seven male patients undergoing surgery with epidural anaesthesia. Five healthy volunteers who did not undergo surgery served as a control group. Paracetamol concentration was measured in saliva at various intervals 1 day before and after surgery. Paracetamol half-life (t1/2,z) decreased and metabolic clearance rate (CL) increased after surgery as compared to preoperative values. The results suggest that surgical stress may enhance the hepatic metabolism of paracetamol.
摘要
在七名接受硬膜外麻醉手术的男性患者中研究了短时间外科手术对乙酰氨基酚消除的影响。五名未接受手术的健康志愿者作为对照组。在手术前一天和手术后的不同时间间隔测量唾液中对乙酰氨基酚的浓度。与术前值相比，术后对乙酰氨基酚的半衰期（t1/2,z）缩短，代谢清除率（CL）增加。结果表明，手术应激可能会增强对乙酰氨基酚的肝脏代谢。
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