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骆驼痘疫苗的基因组测序结果显示与改良安卡拉(MVA)非常相似。

Genome Sequencing of a Camelpox Vaccine Reveals Close Similarity to Modified Ankara (MVA).

机构信息

Istituto Zooprofilattico Sperimentale dell'Abruzzo e Molise, 64100 Teramo, Italy.

Department of Veterinary Medicine, University of Bari, Valenzano, 70010 Bari, Italy.

出版信息

Viruses. 2020 Jul 23;12(8):786. doi: 10.3390/v12080786.

DOI:10.3390/v12080786
PMID:32717784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7472314/
Abstract

Camelpox is a viral contagious disease of Old-World camelids sustained by (CMLV). The disease is characterized by mild, local skin or severe systemic infections and may have a major economic impact due to significant losses in terms of morbidity and mortality, weight loss, and low milk yield. Prevention of camelpox is performed by vaccination. In this study, we investigated the composition of a CMLV-based, live-attenuated commercial vaccine using next-generation sequencing (NGS) technology. The results of this analysis revealed genomic sequences of Modified Ankara (MVA).

摘要

骆驼痘是一种由(骆驼痘病毒)引起的旧世界骆驼属动物的病毒性传染病。这种疾病的特征是轻微的局部皮肤感染或严重的全身性感染,由于发病率和死亡率、体重减轻和产奶量低造成的重大经济损失,该病可能会产生重大的经济影响。骆驼痘的预防是通过接种疫苗来实现的。在这项研究中,我们使用下一代测序(NGS)技术研究了一种基于骆驼痘病毒的、减毒的商业疫苗的组成。该分析的结果显示了改良安卡拉(MVA)的基因组序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e79/7472314/a3ba9ab9a669/viruses-12-00786-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e79/7472314/a3ba9ab9a669/viruses-12-00786-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e79/7472314/a3ba9ab9a669/viruses-12-00786-g001.jpg

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