Turan Demet, Doğan Deniz, Çörtük Mustafa, Uğur Chousein Efsun Gonca, Tanrıverdi Elif, Yıldırım Binnaz Zeynep, Demirkol Barış, Çınarka Halit, Özgül Mehmet Akif, Çetinkaya Erdoğan
Clinic of Chest Diseases, Yedikule Chest Diseases and Chest Surgery Training and Research Hospital, Istanbul, Turkey.
Department of Chest Diseases, Faculty of Gulhane Medicine, Health Sciences University, Ankara, Turkey.
Tuberk Toraks. 2020 Mar;68(1):17-24. doi: 10.5578/tt.69320.
The lung volume reduction coil treatment is a minimally invasive bronchoscopic treatment option for emphysema patients who suffer from severe hyperinflation. Previous studies have reported successful outcomes in selected cases using coil for bronchoscopic lung volume reduction (BLVR). Our aim is to determine the changes in respiratory function tests, perception of dyspnea and exercise capacities after 12 months in patients treated with endobronchial coil.
The data of patients with severe emphysema and treated with coils between 2014-2017 were evaluated retrospectively. Dynamic and static lung volume capacities at baseline and 12 months, modified Medical Research Council (mMRC) questionnaire and six-minute walk test (6-MWT) results were recorded.
BLVR was performed in thirty patients (one female, twenty-nine males). Five patients were treated bilaterally and twentyfive unilaterally. One patient died after 7 days and 4 patients died during follow-up. Five patients were lost to follow-up. A total of twenty patients with available data were included in the study. A statistically significant difference was found in mMRC results in pre-treatment and 12-month evaluations. There was no significant difference in FEV1, TLC and RV values at the end of 12 months. There was an increase of 18.9 meters (± 83.5 m) between the baseline and 12 months in 6-MWT. 45% of the patients improved their walking distance over 26 meters which is known as minimal clinically important difference (MCID).
Although no significant changes were observed in pulmonary function tests and lung volumes, the increase in exercise capacity and decreased perception of dyspnea indicate the efficacy of endobronchial coil.
肺减容线圈治疗是一种针对患有严重肺过度充气的肺气肿患者的微创支气管镜治疗选择。先前的研究报告了在部分使用线圈进行支气管镜肺减容（BLVR）的病例中取得了成功结果。我们的目的是确定接受支气管内线圈治疗的患者在12个月后呼吸功能测试、呼吸困难感知和运动能力的变化。
回顾性评估2014年至2017年间接受线圈治疗的重度肺气肿患者的数据。记录基线和12个月时的动态和静态肺容量、改良医学研究委员会（mMRC）问卷以及六分钟步行试验（6-MWT）结果。
对30例患者（1例女性，29例男性）进行了BLVR。5例患者双侧治疗，25例单侧治疗。1例患者在7天后死亡，4例患者在随访期间死亡。5例患者失访。共有20例有可用数据的患者纳入研究。在治疗前和12个月评估的mMRC结果中发现有统计学意义的差异。12个月结束时，FEV1、TLC和RV值无显著差异。6-MWT在基线和12个月之间增加了18.9米（±83.5米）。45%的患者步行距离改善超过26米，这被称为最小临床重要差异（MCID）。
尽管在肺功能测试和肺容量方面未观察到显著变化，但运动能力的提高和呼吸困难感知的降低表明支气管内线圈治疗有效。
