Multiple Sclerosis and Neuroimmunology Program, Neurological Institute, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Multiple Sclerosis and Neuroimmunology Program, Neurological Institute, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA; Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Clin Lab Med. 2020 Sep;40(3):305-316. doi: 10.1016/j.cll.2020.05.004. Epub 2020 Jul 2.
The recent discovery of several neuronal autoantibodies linked to neurologic syndromes that are fully or partially responsive to immunosuppressive therapy has revolutionized neuroimmunology and expanded the scope of classical paraneoplastic and antibody-related syndromes. A great deal of understanding of the techniques of neuronal antibody testing, the sensitivity and specificity of serum and cerebrospinal fluid sampling, and the value of the specific type and titer of each antibody is imperative. This article provides an overview of neuronal antibody and paraneoplastic panel testing with emphasis on how to differentiate clinically relevant from clinically irrelevant results and the downstream implications of those results.
最近发现了几种与神经综合征相关的神经元自身抗体，这些抗体对免疫抑制治疗有完全或部分反应，这一发现彻底改变了神经免疫学，并扩大了经典副肿瘤和抗体相关综合征的范围。深入了解神经元抗体检测技术、血清和脑脊液采样的敏感性和特异性，以及每种抗体的具体类型和滴度的价值至关重要。本文概述了神经元抗体和副肿瘤抗体检测，重点介绍了如何区分临床相关和临床不相关的结果，以及这些结果的下游影响。
