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内镜和手术治疗胃轻瘫:该做什么,该治疗谁?

Endoscopic and Surgical Treatments for Gastroparesis: What to Do and Whom to Treat?

机构信息

Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, 3401 N. Broad St, Suite C-501. Philadelphia, PA, 19140, USA.

Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, 3401 N. Broad St, Suite C-501. Philadelphia, PA, 19140, USA.

出版信息

Gastroenterol Clin North Am. 2020 Sep;49(3):539-556. doi: 10.1016/j.gtc.2020.04.008. Epub 2020 Jun 20.

DOI:10.1016/j.gtc.2020.04.008
PMID:32718569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7391056/
Abstract

Gastroparesis is a complex chronic debilitating condition of gastric motility resulting in the delayed gastric emptying and multiple severe symptoms, which may lead to malnutrition and dehydration. Initial management of patients with gastroparesis focuses on the diet, lifestyle modification and medical therapy. Various endoscopic and surgical interventions are reserved for refractory cases of gastroparesis, not responding to conservative therapy. Pyloric interventions, enteral access tubes, gastric electrical stimulator and gastrectomy have been described in the care of patients with gastroparesis. In this article, the authors review current management, indications, and contraindications to these procedures.

摘要

胃轻瘫是一种复杂的慢性胃动力障碍性疾病,导致胃排空延迟和多种严重症状,可能导致营养不良和脱水。胃轻瘫患者的初始治疗侧重于饮食、生活方式改变和药物治疗。对于保守治疗无效的难治性胃轻瘫病例,保留各种内镜和手术干预措施。幽门干预、肠内通路管、胃电刺激和胃切除术已用于胃轻瘫患者的治疗。本文作者回顾了这些手术的当前治疗方法、适应证和禁忌证。

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本文引用的文献

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Sleeve gastrectomy for treatment of delayed gastric emptying-indications, technique, and results.袖状胃切除术治疗胃排空延迟:适应证、技术和结果。
Langenbecks Arch Surg. 2020 Feb;405(1):107-116. doi: 10.1007/s00423-020-01856-5. Epub 2020 Jan 20.
2
Gastric peroral endoscopic pyloromyotomy for refractory gastroparesis: a systematic review of early outcomes with pooled analysis.经口内镜下幽门肌切开术治疗难治性胃轻瘫:早期结果的系统评价和汇总分析。
Gastrointest Endosc. 2020 Apr;91(4):746-752.e5. doi: 10.1016/j.gie.2019.11.039. Epub 2019 Dec 3.
3
Open-label pilot study: Non-invasive vagal nerve stimulation improves symptoms and gastric emptying in patients with idiopathic gastroparesis.开放标签的试点研究:无创迷走神经刺激改善特发性胃轻瘫患者的症状和胃排空。
Neurogastroenterol Motil. 2020 Apr;32(4):e13769. doi: 10.1111/nmo.13769. Epub 2019 Dec 5.
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Gastric Electrical Stimulation Reduces Refractory Vomiting in a Randomized Crossover Trial.胃电刺激减少随机交叉试验中的难治性呕吐。
Gastroenterology. 2020 Feb;158(3):506-514.e2. doi: 10.1053/j.gastro.2019.10.018. Epub 2019 Oct 21.
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Effectiveness of gastric electrical stimulation in gastroparesis: Results from a large prospectively collected database of national gastroparesis registries.胃电刺激治疗胃轻瘫的疗效:来自全国胃轻瘫登记处大型前瞻性数据库的结果。
Neurogastroenterol Motil. 2019 Dec;31(12):e13714. doi: 10.1111/nmo.13714. Epub 2019 Oct 4.
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Clinical efficacy of gastric per-oral endoscopic myotomy (G-POEM) in the treatment of refractory gastroparesis and predictors of outcomes: a systematic review and meta-analysis using surgical pyloroplasty as a comparator group.经口内镜下胃肌切开术(G-POEM)治疗难治性胃瘫的临床疗效及结局预测因素:以手术幽门成形术为对照组的系统评价和荟萃分析。
Surg Endosc. 2020 Aug;34(8):3352-3367. doi: 10.1007/s00464-019-07135-9. Epub 2019 Oct 3.
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Surgical Treatment for Refractory Gastroparesis: Stimulator, Pyloric Surgery, or Both?难治性胃轻瘫的手术治疗:刺激器、幽门手术还是两者兼用?
J Gastrointest Surg. 2020 Oct;24(10):2204-2211. doi: 10.1007/s11605-019-04391-x. Epub 2019 Sep 11.
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Gastric Electric Stimulation for Refractory Gastroparesis.胃电刺激治疗难治性胃轻瘫
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Jejunostomy-technique and controversies.空肠造口术——技术与争议
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Surg Endosc. 2020 Apr;34(4):1847-1855. doi: 10.1007/s00464-019-06951-3. Epub 2019 Jul 11.