Institut Pasteur CNRS UMR 3571 Department of Neuroscience and Collège de France, Paris France.
Sorbonne Université, Inserm UMRS, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris).
C R Biol. 2020 Jun 5;343(1):33-39. doi: 10.5802/crbiol.8.
SARS-CoV-2 epidemics raises a considerable issue of public health at the planetary scale. There is a pressing urgency to find treatments based upon currently available scientific knowledge. Therefore, we tentatively propose a hypothesis which hopefully might ultimately help save lives. Based on the current scientific literature and on new epidemiological data which reveal that current smoking status appears to be a protective factor against the infection by SARS-CoV-2 [1], we hypothesize that the nicotinic acetylcholine receptor (nAChR) plays a key role in the pathophysiology of Covid-19 infection and might represent a target for the prevention and control of Covid-19 infection.
SARS-CoV-2 疫情在全球范围内引发了相当大的公共卫生问题。根据现有科学知识，迫切需要寻找治疗方法。因此，我们暂时提出一个假设，希望最终能够帮助拯救生命。基于当前的科学文献和新的流行病学数据，这些数据表明当前的吸烟状况似乎是预防 SARS-CoV-2 感染的保护因素[1]，我们假设烟碱型乙酰胆碱受体（nAChR）在 Covid-19 感染的病理生理学中起着关键作用，并且可能成为预防和控制 Covid-19 感染的目标。
