Zhang Xue, Zhao Kun, Li Na, Yu Jie, Gong Liu-Zhu, Gu Zhenhua
Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, Center for Excellence in Molecular Synthesis, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui, 230026, P. R. China.
Department of Applied Chemistry, Anhui Agricultural University, Hefei, Anhui, 230026, P. R. China.
Angew Chem Int Ed Engl. 2020 Nov 2;59(45):19899-19904. doi: 10.1002/anie.202008431. Epub 2020 Aug 31.
The present work demonstrates a CuCl and anionic chiral cobalt(III)-catalyzed enantioselective ring-opening reaction. The small-size, ligand-free copper species enabled the cross-coupling of iodonium salts with a series of bulky aromatic amines in high ee values. The chiral cobalt(III) anion causes appreciable chemical shift changes of cyclic diaryliodoniums in H NMR spectra.
本研究展示了一种氯化亚铜和手性阴离子钴（III）催化的对映选择性开环反应。这种小尺寸、无配体的铜物种能够使碘鎓盐与一系列体积较大的芳香胺进行交叉偶联，对映体过量值较高。手性钴（III）阴离子在氢核磁共振谱中会引起环状二芳基碘鎓盐明显的化学位移变化。
