Unit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, 9310University of Pisa, Pisa, Italy.
Diagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, 9310University of Pisa, Pisa, Italy.
Can Assoc Radiol J. 2021 Aug;72(3):418-431. doi: 10.1177/0846537120940684. Epub 2020 Jul 28.
Ultra-high frequency ultrasonography (UHFUS) is a recently introduced diagnostic technique which finds several applications in diverse clinical fields. The range of frequencies between 30 and 100 MHz allows for high spatial resolution imaging of superficial structures, making this technique suitable for the imaging of skin, blood vessels, musculoskeletal anatomy, oral mucosa, and small parts. However, the current clinical applications of UHFUS have never been analyzed in a consistent multidisciplinary manner. The aim of this study is to revise and discuss the current applications of UHFUS in different aspects of research and clinical practice, as well as to provide some examples of the current work-in-progress carried out in our center.
A literature search was performed in order to retrieve articles reporting the applications of UHFUS both in research and in clinical settings. Inclusion criteria were the use of frequencies above 30 MHz and study design conducted in vivo on human subjects.
In total 66 articles were retrieved. The majority of the articles focused on dermatological and vascular applications, although musculoskeletal and intraoral applications are emerging fields of use. We also describe our experience in the use of UHFUS as a valuable diagnostic support in the fields of dermatology, rheumatology, oral medicine, and musculoskeletal anatomy.
Ultra-high frequency ultrasonography application involves an increasing number of medical fields. The high spatial resolution and the superb image quality achievable allow to foresee a wider use of this novel technique, which has the potential to bring innovation in diagnostic imaging.
超高频超声（UHFUS）是一种最近引入的诊断技术，在多个临床领域有多种应用。频率范围在 30 至 100MHz 之间，可实现对浅表结构的高空间分辨率成像，因此非常适合对皮肤、血管、肌肉骨骼解剖结构、口腔黏膜和小部位进行成像。然而，目前尚未以一致的多学科方式对 UHFUS 的临床应用进行分析。本研究旨在修订并讨论 UHFUS 在研究和临床实践的不同方面的当前应用，并提供我们中心目前正在进行的一些工作实例。
为了检索报告 UHFUS 在研究和临床环境中的应用的文章，我们进行了文献检索。纳入标准为使用频率高于 30MHz 和在人体上进行的体内研究设计。
共检索到 66 篇文章。大多数文章都集中在皮肤科和血管应用方面，尽管肌肉骨骼和口腔内应用是新兴的应用领域。我们还描述了我们在皮肤科、风湿病学、口腔医学和肌肉骨骼解剖学领域将 UHFUS 用作有价值的诊断支持的经验。
超高频超声应用涉及越来越多的医学领域。高空间分辨率和出色的图像质量可预见这项新技术的更广泛应用，它有可能为诊断成像带来创新。
