Hendry S H, Jones E G
Department of Anatomy and Neurobiology, University of California, Irvine 92717.
Neuron. 1988 Oct;1(8):701-12. doi: 10.1016/0896-6273(88)90169-9.
Levels of the inhibitory transmitter, GABA, and its synthesizing enzyme, GAD, appear to be regulated in the visual cortex of young adult monkeys in an activity-dependent manner. In monkeys subjected to monocular deprivation by eye removal, tetrodotoxin injection, or eyelide suture, the number of GABA and GAD immunoreactive neurons in deprived-eye columns of the cortex is reduced by up to 50%. This effect is unaccompanied by cell death and is reversible. After cessation of TTX injection or reopening of the eyes, the number of immunostained cells returns to normal. The effect appears after 4-5 days of eye removal or tetrodotoxin injection, but only after 7-16 weeks of eyelid suture. In the latter case, it is more severe in the younger monkeys. The reversible reduction in GABA and GAD immunostaining extends out of layer IVC into lay IVA and to neurons around but not in cytochrome oxidase periodicities of layer III. This may indicate selective vulnerability of GABA cells sensitive to high spatial frequency.
抑制性递质γ-氨基丁酸（GABA）及其合成酶谷氨酸脱羧酶（GAD）的水平，在成年幼猴的视皮层中似乎以一种活动依赖的方式受到调节。在通过摘除眼球、注射河豚毒素或缝合眼睑进行单眼剥夺的猴子中，皮层中剥夺眼柱内GABA和GAD免疫反应性神经元的数量减少了多达50%。这种效应不伴有细胞死亡且是可逆的。停止注射河豚毒素或重新睁开眼睛后，免疫染色细胞的数量恢复正常。这种效应在摘除眼球或注射河豚毒素4 - 5天后出现，但仅在眼睑缝合7 - 16周后出现。在后一种情况下，年幼猴子的情况更严重。GABA和GAD免疫染色的可逆减少从IVC层延伸到IVA层，并延伸到III层细胞色素氧化酶周期周围但不在其中的神经元。这可能表明对高空间频率敏感的GABA细胞具有选择性易损性。
