Asakura Toshihisa, Nakai Yasutomo, Oka Toshiki, Okuda Yohei, Hatano Koji, Nakayama Masashi, Kakimoto Kenichi, Nishimura Kazuo
The Department of Urology, Osaka International Cancer Institute.
Hinyokika Kiyo. 2020 Jul;66(7):225-228. doi: 10.14989/ActaUrolJap_66_7_225.
The patient a 48-year-old male, underwent nephrectomy for clear cell renal cell carcinoma. After surgery, the patient was treated sequentially with sunitinib, axitinib, and everolimus for multiple pulmonary metastases and iliopsoas muscle metastasis. After 16 months, subcutaneous metastasis and left ventricular myocardial metastasis developed without any symptoms. He was treated with pazopanib for these metastases. However, no shrinkage was seen and bone metastasis in right acetabulum appeared. After radiation therapy (20 Gy/5 Fr) for right acetabulum, nivolumab was administered for myocardial metastasis and subcutaneous metastasis. Significant shrinkage of metastases was seen after 3 courses of nivolumab and the patient's condition remained stable after 31 courses of nivolumab.
该患者为一名48岁男性，因透明细胞肾细胞癌接受了肾切除术。术后，该患者先后接受舒尼替尼、阿昔替尼和依维莫司治疗，以应对多处肺转移和髂腰肌转移。16个月后，出现皮下转移和左心室心肌转移，且无任何症状。针对这些转移灶，他接受了帕唑帕尼治疗。然而，未见病灶缩小，右侧髋臼出现骨转移。在对右侧髋臼进行放射治疗（20 Gy/5次分割）后，针对心肌转移和皮下转移给予纳武单抗治疗。在接受3个疗程的纳武单抗治疗后，转移灶明显缩小，在接受31个疗程的纳武单抗治疗后，患者病情保持稳定。
