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自体干细胞治疗糖尿病足：随机研究的荟萃分析

Treatment of Diabetic Foot with Autologous Stem Cells: A Meta-Analysis of Randomized Studies.

作者信息

Dai Jiezhi, Jiang Chaoyin, Chen Hua, Chai Yimin

机构信息

Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.

出版信息

Stem Cells Int. 2020 Jul 16;2020:6748530. doi: 10.1155/2020/6748530. eCollection 2020.

DOI:10.1155/2020/6748530
PMID:32724314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7381994/
Abstract

BACKGROUND

This meta-analysis was to evaluate the efficacy of autologous stem cell administration for the treatment of diabetic foot.

METHODS

The electronic databases included PubMed, EMBASE, BIOSIS, Cochrane central, and Google Scholar internet, last updated on May 30, 2019. Evaluated outcomes included the rate of wound healing and amputation. Dichotomous outcomes were described as risk ratios (RR) with 95% confidence intervals (CIs). Statistical analysis was performed with RevMan 5.0 software and STATA 10.0 software.

RESULTS

Eight randomized controlled trial (RCT) studies were included in this study. The meta-analysis showed a lower amputation (RR 0.25, 95% CI 0.11 to 0.54, = 0) and a higher wound healing rate (RR 2.05, 95% CI 1.67 to 2.51, = 4) in the cell therapy group compared with control.

CONCLUSION

This meta-analysis supports the effective role of stem cell therapy in promoting wound healing and decreasing rate of amputation in diabetic foot. In the future, more high quality and well-designed studies are need.

摘要

背景

本荟萃分析旨在评估自体干细胞给药治疗糖尿病足的疗效。

方法

电子数据库包括PubMed、EMBASE、BIOSIS、Cochrane中心和谷歌学术搜索，最后更新时间为2019年5月30日。评估的结果包括伤口愈合率和截肢率。二分法结果以风险比（RR）及95%置信区间（CI）描述。采用RevMan 5.0软件和STATA 10.0软件进行统计分析。

结果

本研究纳入了8项随机对照试验（RCT）研究。荟萃分析显示，与对照组相比，细胞治疗组截肢率较低（RR 0.25，95%CI 0.11至0.54，P = 0），伤口愈合率较高（RR 2.05，95%CI 1.67至2.51，P = 4）。

结论

本荟萃分析支持干细胞治疗在促进糖尿病足伤口愈合和降低截肢率方面的有效作用。未来，需要更多高质量、设计良好的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/ca7f90956a8f/SCI2020-6748530.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/eb810e11a3cb/SCI2020-6748530.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/6d7f92af9c18/SCI2020-6748530.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/21e36fa9a2b4/SCI2020-6748530.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/ca7f90956a8f/SCI2020-6748530.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/eb810e11a3cb/SCI2020-6748530.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/6d7f92af9c18/SCI2020-6748530.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/21e36fa9a2b4/SCI2020-6748530.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fd89/7381994/ca7f90956a8f/SCI2020-6748530.004.jpg

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Autologous cells derived from different sources and administered using different regimens for 'no-option' critical lower limb ischaemia patients.来自不同来源的自体细胞，针对“无其他选择”的严重下肢缺血患者，采用不同方案进行给药。
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