School of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.
Diabetic Foot Australia, West End, QLD, 4101, Australia.
Syst Rev. 2017 May 18;6(1):101. doi: 10.1186/s13643-017-0488-5.
Diabetic foot disease is associated with major morbidity, mortality, costs, and reduction of a person's quality of life. Investigating the epidemiology of diabetic foot disease is the backbone of diabetic foot research and clinical practice, yet the full burden of diabetic foot disease in Australia is unknown. This study aims to describe the protocol for a systematic review of the epidemiology of diabetic foot disease and diabetes-related lower-extremity amputation in Australia.
METHODS-SEARCH: The systematic review will be performed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. PubMed and EMBASE will be searched for publications in any language and without restrictions to date. Two independent investigators will screen publications for eligibility, with publications reporting Australian population-based incidence or prevalence of diabetic foot disease or diabetes-related lower-extremity amputation to be included. Additionally, a forward literature search will be performed in Google Scholar, and a grey literature search will be performed to identify government publications.
METHODS-ASSESSMENT: Quality assessment will be performed using customised checklists. The summary statistic used for each study will be an incidence or prevalence proportion of diabetic foot disease or diabetes-related lower-extremity amputation. The standard error for each proportion will be calculated. A meta-analysis will be performed when three or more publications of adequate quality, reporting on similar outcomes and in similar populations, are identified.
The results of this systematic review can be used to adequately inform stakeholders in the field of diabetic foot disease on the extent of the problem in incidence and prevalence of diabetic foot disease in Australia, and to help guide appropriate use of resources to reduce the burden of this disease.
PROSPERO CRD42016050740.
糖尿病足病与重大发病率、死亡率、成本以及降低个人生活质量有关。研究糖尿病足病的流行病学是糖尿病足研究和临床实践的基础，但澳大利亚糖尿病足病的全部负担尚不清楚。本研究旨在描述一项关于澳大利亚糖尿病足病和糖尿病相关下肢截肢流行病学的系统评价方案。
方法-检索：该系统评价将根据系统评价和荟萃分析的首选报告项目进行。将以任何语言和无日期限制搜索 PubMed 和 EMBASE 中的出版物。两名独立的调查员将对出版物进行筛选，以确定其是否符合入选标准，报告澳大利亚人群中糖尿病足病或糖尿病相关下肢截肢的发病率或患病率的出版物将被纳入。此外，还将在 Google Scholar 中进行前瞻性文献搜索，并进行灰色文献搜索以确定政府出版物。
方法-评估：将使用定制的清单进行质量评估。每项研究使用的汇总统计数据将是糖尿病足病或糖尿病相关下肢截肢的发病率或患病率。将计算每个比例的标准误差。当确定有三个或更多具有足够质量、报告相似结果和相似人群的出版物时，将进行荟萃分析。
本系统评价的结果可用于向糖尿病足病领域的利益相关者充分告知澳大利亚糖尿病足病发病率和患病率的问题程度，并有助于指导适当利用资源来减轻该疾病的负担。
PROSPERO CRD42016050740。
