Corella Sánchez R, Reyes Díaz J M
Rev Cubana Estomatol. 1988 Sep-Dec;25(3):55-64.
The study of acute herpetic gingivostomatitis (AHGS) has been a very interesting theme for those dealing with periodontal practice. The majority of the authors states the application of symptomatic treatment for such disease and there is a nearly universal criterium that its lesions can be maintained up to 14 days. We decided to star a searching in the up-to-date literature and we found some very serious studies where was stated, among other statements, the application of a specific chemotherapy using an analogous pyrimidine: iodoxuridine. Since then, we started the study of AHGS in 20 children with clinical diagnosis of such disease. In 10 children a symptomatic treatment was applied and in the rest topical applications of collyrium of 0.1% iodoxuridine, three times a day. Both groups were appointed after three, seven and ten days of being under treatment in order to verify the evolution of symptoms (pain) and signs vesicles or ulcer). It was observed that either lesions or pain disappeared in a shortly time in those children treated with iodoxuridine, without side effects. It is concluded that the use of this drug was effective for our patients and, therefore, we suggest its study and application.
对于从事牙周治疗工作的人来说，急性疱疹性龈口炎（AHGS）的研究一直是一个非常有趣的课题。大多数作者主张对此类疾病采用对症治疗，并且存在一个几乎通用的标准，即其病损可持续长达14天。我们决定在最新文献中进行检索，发现了一些非常严谨的研究，其中提到了使用一种类似嘧啶的特定化疗药物：碘苷。从那时起，我们开始对20名临床诊断为此类疾病的儿童进行AHGS研究。10名儿童采用对症治疗，其余儿童每天三次局部应用0.1%碘苷眼药水。两组患儿在治疗3天、7天和10天后进行检查，以核实症状（疼痛）和体征（水疱或溃疡）的演变情况。观察发现，使用碘苷治疗的患儿病损和疼痛在短时间内消失，且无副作用。得出的结论是，该药物对我们的患者有效，因此，我们建议对其进行研究和应用。
