Atif Muhammad, Fatima Razia, Ahmad Nafees, Babar Zaheer-Ud-Din
Department of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Punjab Pakistan.
Research Unit, National TB Control Program, Islamabad, Pakistan.
J Pharm Policy Pract. 2020 Jul 24;13:35. doi: 10.1186/s40545-020-00227-1. eCollection 2020.
There is limited published data form Pakistan on treatment success rate among extrapulmonary tuberculosis (EPTB) patients. The aim of this study was to assess clinical form, treatment outcomes, and identify the factors associated with unfavorable treatment outcome among EPTB patients.
A retrospective study was conducted at the Chest Disease Unit of the Bahawal Victoria Hospital, Pakistan. Medical records of EPTB patients, registered at the study site from January 1, 2015 to September 30, 2017, were reviewed to obtain the data. Final treatment outcomes among EPTB patients were evaluated in accordance with the standard Word Health Organization (WHO) criteria. Multivariate binary logistic regression analysis was used to identify the factors associated with unfavorable treatment outcome.
A total of 651 EPTB patients were included in the study. Highest proportion of patients had pleural TB ( = 217, 33.3%). Out of the total 651 patients, 463 (71.1%) successfully completed the treatment. Among 177 (27.2%) patients with unfavorable treatment outcome, 10 (1.5%) died, while 165 (25.4%) lost to follow-up the treatment. Lymph node TB (AOR 0.65, 95% CI 0.422, 0.989) and meningeal TB (AOR 2.1, 95% CI 1.065, 4.144) were significantly associated with unfavorable treatment outcome.
The treatment success (favorable outcome) rate among EPTB patients was less than the target (i.e., ≥ 90%) set by the WHO. Highest proportion of patients lost to follow-up during the treatment.
巴基斯坦关于肺外结核病（EPTB）患者治疗成功率的已发表数据有限。本研究的目的是评估EPTB患者的临床类型、治疗结果，并确定与不良治疗结果相关的因素。
在巴基斯坦巴哈瓦尔维多利亚医院胸科进行了一项回顾性研究。回顾了2015年1月1日至2017年9月30日在研究地点登记的EPTB患者的病历以获取数据。根据世界卫生组织（WHO）的标准评估EPTB患者的最终治疗结果。采用多变量二元逻辑回归分析来确定与不良治疗结果相关的因素。
本研究共纳入651例EPTB患者。胸膜结核患者比例最高（n = 217，33.3%）。在651例患者中，463例（71.1%）成功完成治疗。在177例（27.2%）治疗结果不佳的患者中，10例（1.5%）死亡，165例（25.4%）失访。淋巴结结核（调整后比值比[AOR]0.65，95%置信区间[CI]0.422，0.989）和脑膜结核（AOR 2.1，95% CI 1.065，4.144）与不良治疗结果显著相关。
EPTB患者的治疗成功率（良好结局）低于世界卫生组织设定的目标（即≥90%）。治疗期间失访患者比例最高。
