Isacco Ciro Gargiulo, Ballini Andrea, De Vito Danila, Nguyen Kieu Cao Diem, Cantore Stefania, Bottalico Lucrezia, Quagliuolo Lucio, Boccellino Mariarosaria, Di Domenico Marina, Santacroce Luigi, Arrigoni Roberto, Dipalma Gianna, Inchingolo Francesco
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 80100 Naples, Italy.
Endocr Metab Immune Disord Drug Targets. 2021;21(5):777-784. doi: 10.2174/1871530320666200729142504.
The current treatment and prevention procedures of oral disorders follow a very targeted approach considering mouth and its structures as a system that is completely independent, than the rest of the body. The main therapeutic approach is to keep the levels of oral bacteria and hygiene in an acceptable range compatible with oral-mouth health, completely separated from systemic microbial homeostasis (eubiosis vs dysbiosis). This can negatively impact the diagnosis of a more complex systemic disease and its progression. Dysbiosis occurs as a consequence of imbalance in oral and gut microbiota which leads to cardiovascular diseases, diabetes mellitus, rheumatoid arthritis, and Alzheimer's disease, as reported in current literature. Likewise, there is a need to highlight and develop a novel philosophical approach in the treatments for oral diseases that will necessarily involve nonconventional approaches.
目前口腔疾病的治疗和预防程序采用的是一种非常有针对性的方法，将口腔及其结构视为一个完全独立于身体其他部分的系统。主要的治疗方法是将口腔细菌水平和口腔卫生保持在与口腔健康相容的可接受范围内，与全身微生物稳态（正常微生物群与失调微生物群）完全分开。这可能会对更复杂的全身性疾病的诊断及其进展产生负面影响。正如当前文献所报道的，失调微生物群是口腔和肠道微生物群失衡的结果，会导致心血管疾病、糖尿病、类风湿性关节炎和阿尔茨海默病。同样，有必要突出并开发一种新的口腔疾病治疗哲学方法，这种方法必然会涉及非传统方法。
