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分析在学术和社区环境中新出现的葡萄膜炎病例。

Analysis of new cases of uveitis at academic and community settings.

机构信息

Ocular Immunology Division, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, USA

Ocular Immunology Division, Johns Hopkins Wilmer Eye Institute, Baltimore, Maryland, USA.

出版信息

Br J Ophthalmol. 2021 Jun;105(6):779-782. doi: 10.1136/bjophthalmol-2020-316651. Epub 2020 Jul 29.

Abstract

PURPOSE

Describe the demographics of new patients with uveitis presenting to an urban, academic centre and affiliated, suburban satellite clinics to assess if changes in infrastructure were needed for clinical care. Secondarily, examine the frequency of infectious uveitides.

METHODS

A retrospective chart review of single academic centre of 436 consecutive, new patients with uveitis (686 eyes) and 3 affiliated, satellite clinics seen by 8 uveitis specialists from 1 July 2013 to 31 March 2017. Demographics recorded included patient age, race, associated systemic disease, uveitis chronicity, and anatomic location. The main outcome measure was comparing frequencies of patient demographics, immunosuppressive agent use, and infectious uveitis between locations.

RESULTS

366 patients (587 eyes) were evaluated at the academic clinic and 70 (99 eyes) at the satellite locations. Anterior uveitis was the most common anatomic location; more acute, unilateral cases were seen at satellites (p=0.007; p=0.002, respectively). A larger percentage of posterior and panuveitis cases presented to the academic centre (p<0.0001). There was no difference in systemic disease association (p=0.925) or infectious uveitis cases (p=0.956). The use of non-corticosteroid immunosuppressive medications was higher at the academic clinic (p<0.001).

CONCLUSIONS

Anterior uveitis comprised the majority of cases in both clinics. Non-corticosteroid immunosuppressive agents were used more frequently at the academic clinic, reflecting more cases of chronic posterior and panuveitis. Compounded intravitreal injections, specialised ophthalmic imaging studies and high-risk medication monitoring can be centralised in the academic clinic. Infectious uveitis cases were seen at both locations, with an increase in syphilis diagnoses at the academic centre.

摘要

目的

描述在城市学术中心及其附属郊区卫星诊所就诊的新葡萄膜炎患者的人口统计学特征,以评估临床护理是否需要改变基础设施。其次,检查感染性葡萄膜炎的频率。

方法

对 2013 年 7 月 1 日至 2017 年 3 月 31 日期间在一家学术中心就诊的 436 例(686 只眼)新葡萄膜炎患者和 8 位葡萄膜炎专家在 3 家附属卫星诊所就诊的 70 例(99 只眼)患者进行回顾性图表分析。记录的人口统计学数据包括患者年龄、种族、合并的全身疾病、葡萄膜炎的慢性程度和解剖部位。主要观察指标是比较不同地点患者的人口统计学特征、免疫抑制剂的使用情况和感染性葡萄膜炎的频率。

结果

366 例(587 只眼)患者在学术中心就诊,70 例(99 只眼)患者在卫星诊所就诊。前葡萄膜炎是最常见的解剖部位;卫星诊所更常见急性单侧病例(p=0.007;p=0.002)。更多的后葡萄膜炎和全葡萄膜炎患者到学术中心就诊(p<0.0001)。全身疾病的相关性(p=0.925)或感染性葡萄膜炎病例(p=0.956)无差异。学术中心非皮质类固醇免疫抑制剂的使用率更高(p<0.001)。

结论

两种诊所均以前葡萄膜炎为主。学术中心更频繁地使用非皮质类固醇免疫抑制剂,反映出更多的慢性后葡萄膜炎和全葡萄膜炎病例。复合玻璃体内注射、专门的眼科影像学研究和高危药物监测可以在学术中心集中进行。感染性葡萄膜炎在两个地点都有发现,学术中心梅毒诊断有所增加。

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