Department of Surgery, Uijeongbu St. Mary Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Surgery, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Anticancer Res. 2020 Aug;40(8):4537-4545. doi: 10.21873/anticanres.14459.
BACKGROUND/AIM: Altered connexin expression has been associated with cancer development and progression. This study evaluated connexin 26, 32, and 43 expression in association with the long-term outcomes of gastric cancer after gastrectomy.
Pathological specimens were collected from 113 patients who underwent gastrectomy for gastric cancer, of whom 104 were included in the study. The expression levels of the connexins were assessed by immunohistochemistry. The patients were classified into low and high groups according to the median histoscore of connexin.
Cancer-specific survival (CSS) was significantly longer in the high than low connexin 43 group (p=0.030), particularly in patients >65 years old (p=0.030). A multivariate analysis identified pathological stage, differentiation type, and connexin 43 expression as possible predictors of CSS in patients (difference in the area under the curve=0.232, 0.090, and 0.094).
Low connexin 43 expression predicted a poor CSS in gastric cancer patients after gastrectomy.
背景/目的：连接蛋白表达的改变与癌症的发生和发展有关。本研究评估了连接蛋白 26、32 和 43 的表达与胃癌患者胃切除术后长期预后的关系。
收集了 113 例因胃癌接受胃切除术的患者的病理标本，其中 104 例纳入研究。通过免疫组织化学评估连接蛋白的表达水平。根据连接蛋白的中位组织评分，将患者分为低表达和高表达组。
高连接蛋白 43 组的癌症特异性生存率（CSS）明显长于低表达组（p=0.030），尤其是在>65 岁的患者中（p=0.030）。多因素分析确定了病理分期、分化类型和连接蛋白 43 表达是预测患者 CSS 的可能因素（曲线下面积差异为 0.232、0.090 和 0.094）。
低连接蛋白 43 表达预示着胃癌患者胃切除术后 CSS 较差。
