Department of Esophageal Surgery, Tianjin Medical University Cancer Hospital and Institute, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China.
Department of Esophageal Surgery, Tianjin Medical University Cancer Hospital and Institute, Key Laboratory of Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin, China,
Dig Surg. 2020;37(6):463-471. doi: 10.1159/000508965. Epub 2020 Jul 30.
The present study was to investigate the influence of induction therapy on robot-assisted McKeown esophagectomy (RAME) with radical superior mediastinal lymph node dissection for esophageal squamous cell carcinoma in a high-volume cancer center.
A consecutive patient cohort who underwent RAME from January 2017 to May 2019 were reviewed. The perioperative outcomes of patients with induction therapy were compared with those who had surgery alone.
In total, 118 patients underwent RAME during the study period. The average age was 59.1 ± 7.5 years, including 100 male and 18 female patients. Thirty patients (25.4%) had induction therapy, and 88 patients did not receive induction therapy. The average age of the patients treated with induction therapy was younger than those received surgery alone (56.8 ± 6.1 vs. 59.5 ± 7.6 years, p = 0.039). There were no statistically significant differences in the mean operative time and estimated blood loss between both groups. Complications occurred in 46 (39.0%) patients. There were no statistically significant differences in the rates of any complications between both groups (p = 0.951). There were no deaths in either group. The hospital stay was prolonged in patients with induction therapy than those in the surgery-alone group (20.8 ± 8.9 vs. 16.8 ± 6.0, p = 0.048). There was no statistically significant difference in the average number of dissected lymph nodes in total and both recurrent laryngeal nerve stations between both groups.
For patients with esophageal squamous cell carcinoma, induction therapy has no influence on RAME with radical superior mediastinal lymph node dissection.
本研究旨在探讨在高容量癌症中心，诱导治疗对机器人辅助 McKeown 食管切除术（RAME）联合根治性上纵隔淋巴结清扫术治疗食管鳞癌的影响。
回顾性分析 2017 年 1 月至 2019 年 5 月期间接受 RAME 的连续患者队列。比较接受诱导治疗和单纯手术患者的围手术期结局。
研究期间共有 118 例患者接受 RAME。平均年龄为 59.1±7.5 岁，包括 100 例男性和 18 例女性。30 例（25.4%）患者接受诱导治疗，88 例患者未接受诱导治疗。接受诱导治疗患者的平均年龄小于单纯手术患者（56.8±6.1 岁比 59.5±7.6 岁，p=0.039）。两组间平均手术时间和估计出血量无统计学差异。两组患者并发症发生率无统计学差异（p=0.951）。两组均无死亡病例。诱导治疗组患者的住院时间长于单纯手术组（20.8±8.9 天比 16.8±6.0 天，p=0.048）。两组总淋巴结和双侧喉返神经站的平均淋巴结清扫数量无统计学差异。
对于食管鳞癌患者，诱导治疗对 RAME 联合根治性上纵隔淋巴结清扫术无影响。
