开发和长期评估一种新型基于纳米 SnO 的 Ge/Ga 发生器，用于 PET 成像。

Development and long-term evaluation of a new Ge/Ga generator based on nano-SnO for PET imaging.

机构信息

Biomedical Applications and Pharmacokinetics Unit, CIEMAT, 28040, Madrid, Spain.

Molecular Oncology Unit, CIEMAT, 28040, Madrid, Spain.

出版信息

Sci Rep. 2020 Jul 29;10(1):12756. doi: 10.1038/s41598-020-69659-8.

DOI:10.1038/s41598-020-69659-8

PMID:32728067

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7392752/

Abstract

Radionuclide generator systems can routinely provide radionuclides on demand such as Ga produced by a Ge/Ga generator without the availability of an on-site accelerator or a research reactor. Thus, in this work nano-SnO was used to develop a new Ge/Ga generator which was evaluated over a period of 17 months and 305 elution cycles. The elution yield was 91.1 ± 1.8% in the first 7 mL (1 M HCl as eluent) when the generator was new and then it decreased with time and use to 73.8 ± 1.9%. Around 80% of the elutable Ga activity was obtained in 1 mL and the Ge content in the eluate did not exceed 1 × 10% over the investigation period when it was eluted regularly. The described generator provided adequate results for radiolabelling of DOTA-TOC with direct use of eluate. In addition, [Ga]Ga-DOTA-TOC was tested satisfactorily for in vivo tumor detection by microPET/CT imaging in a lung cancer mouse model.

摘要

放射性核素发生器系统可以按需常规提供放射性核素，例如通过 Ge/Ga 发生器生产的 Ga，而无需现场加速器或研究堆。因此，在这项工作中，使用纳米 SnO 开发了一种新的 Ge/Ga 发生器，该发生器经过了 17 个月和 305 次洗脱循环的评估。当发生器是新的时候，在最初的 7 mL 中（洗脱剂为 1 M HCl）洗脱产率为 91.1±1.8%，然后随着时间的推移和使用而降低至 73.8±1.9%。在研究期间，当定期洗脱时，约 80%的可洗脱 Ga 活性可在 1 mL 中获得，并且洗脱液中的 Ge 含量不超过 1×10%。所描述的发生器可直接使用洗脱液为 DOTA-TOC 进行放射性标记提供了足够的结果。此外，[Ga]Ga-DOTA-TOC 已通过微 PET/CT 成像在肺癌小鼠模型中用于体内肿瘤检测的测试，结果令人满意。