Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-Dong, Dong-Gu, Gwangju, 501-757, Republic of Korea.
Sci Rep. 2020 Jul 29;10(1):12768. doi: 10.1038/s41598-020-69566-y.
The aim of this study was to test the hypothesis that plasma sphingosine 1-phosphate (S1P) levels are associated with the risk of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes patients. This cross-sectional study included 287 individuals with type 2 diabetes. CAN was evaluated using cardiovascular reflex tests. Logistic regression analyses were conducted to assess the relationship between plasma S1P levels and CAN. Plasma S1P concentrations were significantly lower in individuals with CAN than in those without CAN. There was a significant interaction between plasma S1P levels and sex with respect to CAN (p for interaction = 0.003). When stratified by sex, the association between plasma S1P levels and CAN exhibited a sex difference; in multivariable analysis, plasma S1P levels were significantly associated with CAN in women (odds ratio per standard deviation increase in the log-transformed value, 0.40; 95% confidence interval, 0.23-0.70, p = 0.001). However, there was no significant association between plasma S1P and CAN in men. Plasma S1P concentrations were inversely associated with CAN only in women with type 2 diabetes.
本研究旨在验证血浆鞘氨醇 1-磷酸（S1P）水平与 2 型糖尿病患者发生心血管自主神经病变（CAN）风险相关的假设。该横断面研究纳入了 287 名 2 型糖尿病患者。采用心血管反射试验评估 CAN。采用 logistic 回归分析评估血浆 S1P 水平与 CAN 之间的关系。与无 CAN 者相比，CAN 患者的血浆 S1P 浓度显著降低。血浆 S1P 水平与性别对 CAN 的交互作用具有统计学意义（p 交互作用=0.003）。按性别分层后，血浆 S1P 水平与 CAN 之间的关联存在性别差异；在多变量分析中，血浆 S1P 水平与女性的 CAN 显著相关（对数转换值每增加一个标准差的比值比，0.40；95%置信区间，0.23-0.70，p=0.001）。然而，在男性中，血浆 S1P 与 CAN 之间无显著相关性。仅在女性 2 型糖尿病患者中，血浆 S1P 浓度与 CAN 呈负相关。
