内脏脂肪堆积与 2 型糖尿病患者血浆鞘氨醇-1-磷酸水平升高有关。

Visceral fat accumulation is associated with increased plasma sphingosine-1-phosphate levels in type 2 diabetes mellitus.

机构信息

Department of Internal Medicine 1, Shimane University Faculty of Medicine, Shimane 693-8501, Japan.

出版信息

Diabetes Res Clin Pract. 2018 Sep;143:146-150. doi: 10.1016/j.diabres.2018.07.003. Epub 2018 Jul 11.

DOI:10.1016/j.diabres.2018.07.003

PMID:30006309

Abstract

OBJECTIVE

Accumulating evidence has shown that sphingosine-1-phosphate (S1P) plays roles in glucose and fat metabolism. However, the association between plasma S1P levels and fat mass, especially visceral fat mass, remains unknown.

METHODS

In this cross-sectional study, 80 men with type 2 diabetes mellitus (T2DM) were recruited to investigate the association of plasma S1P levels with body fat parameters. Visceral (VFA) and subcutaneous fat (SFA) areas were evaluated by performing computed tomography scan, and fat mass (FM) and lean body mass (LBM) were examined by whole body dual-energy X-ray absorptiometry.

RESULTS

Multiple regression analysis adjusted for age, T2DM duration, serum creatinine, and body mass index (BMI) showed that S1P was significantly and positively associated with fasting plasma glucose (β = 0.25, p = 0.027), HbA1c (β = 0.28, p = 0.012), and urine C-peptide (β = 0.29, p = 0.014). Moreover, multiple regression analysis adjusted for age, T2DM duration, serum creatinine, HbA1c, and urine C-peptide showed that BMI (β = 0.32, p = 0.008), VFA (β = 0.33, p = 0.008), SFA (β = 0.26, p = 0.039), FM (β = 0.37, p = 0.003), and LBM (β = 0.35, p = 0.01). FM was significantly and positively associated with S1P after additional adjustment for LBM (β = 0.29, p = 0.028), whereas LBM was not after adjustment for FM. Moreover, VFA was significantly and positively associated with S1P after additional adjustment for SFA (β = 0.27, p = 0.039), whereas SFA was not after adjustment for VFA.

CONCLUSION

This is the first study to show that increased plasma S1P levels are associated with blood glucose levels and accumulation of fat mass, especially visceral fat mass, in men with T2DM.

摘要

目的

越来越多的证据表明，1-磷酸鞘氨醇（S1P）在葡萄糖和脂肪代谢中发挥作用。然而，血浆 S1P 水平与脂肪量，尤其是内脏脂肪量之间的关系尚不清楚。

方法

在这项横断面研究中，共招募了 80 名 2 型糖尿病（T2DM）男性，以研究血浆 S1P 水平与体脂参数的关系。通过进行计算机断层扫描评估内脏（VFA）和皮下脂肪（SFA）区域，通过全身双能 X 射线吸收法检查脂肪量（FM）和瘦体重（LBM）。

结果

经年龄、T2DM 病程、血清肌酐和体重指数（BMI）校正的多元回归分析表明，S1P 与空腹血糖（β=0.25，p=0.027）、HbA1c（β=0.28，p=0.012）和尿 C 肽（β=0.29，p=0.014）呈显著正相关。此外，经年龄、T2DM 病程、血清肌酐、HbA1c 和尿 C 肽校正的多元回归分析表明，BMI（β=0.32，p=0.008）、VFA（β=0.33，p=0.008）、SFA（β=0.26，p=0.039）、FM（β=0.37，p=0.003）和 LBM（β=0.35，p=0.01）与 S1P 呈显著正相关。在进一步调整 LBM 后，FM 与 S1P 呈显著正相关（β=0.29，p=0.028），而在调整 FM 后，LBM 与 S1P 无关。此外，在进一步调整 SFA 后，VFA 与 S1P 呈显著正相关（β=0.27，p=0.039），而在调整 SFA 后，SFA 与 S1P 无关。