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富血小板纤维蛋白膜在经耳道鼓膜成形术中的新应用:一项前瞻性研究。

Novel Use of Platelet Rich Fibrin Membrane in Transcanal Myringoplasty: A Prospective Study.

作者信息

Shukla Anirudh, Kaurav Yogesh Singh, Vatsyayan Richa

机构信息

Department of ENT, NSCB Government Medical College, Jabalpur, 482003 India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2020 Sep;72(3):355-362. doi: 10.1007/s12070-020-01851-8. Epub 2020 May 8.

Abstract

Being rich in growth factors platelet rich fibrin (PRF) has been used for decades for its healing properties in cosmetic surgeries but its use in transcanal myringoplasty is a novel approach that remains unexplored. In todays era of minimally invasive surgery not only does it provide as a great alternative to conventional myringoplasty but also outshines it. It reduces post operative pain, hospital stay and unlike the conventional technique that uses termporalis fascia as a graft material, PRF myringoplasty if required can be reperformed on the same patient multiple times with minimal risk. This procedure comes as a boon for patients with recurrent graft defects because after multiple revision surgeries, temporalis fascia can be deficient and other graft materials like cartilage/perichondrium or fascia lata etc. have to be harvested surgically for myringoplasty. In PRF myringoplasty there is no upper limit in the number of times the PRF membrane can be made and also it does not entail any surgical incision for graft harvest. A prospective study involving 41 patients was conducted at Netaji Subhash Chandra Bose Medical College, Jabalpur where in the tympanic membrane perforations were repaired using PRF membrane with a successful outcome in 85.4% of the patients included in this study.

摘要

富含生长因子的富血小板纤维蛋白(PRF)因其在整形手术中的愈合特性已被使用数十年,但其在经耳道鼓膜成形术中的应用仍是一种尚未探索的新方法。在当今的微创手术时代,它不仅是传统鼓膜成形术的绝佳替代方法,而且还更胜一筹。它能减轻术后疼痛、缩短住院时间,并且与使用颞肌筋膜作为移植材料的传统技术不同,如果需要,PRF鼓膜成形术可以在同一患者身上多次重复进行,风险极小。对于复发性移植缺损的患者来说,这个手术是一大福音,因为在多次翻修手术后,颞肌筋膜可能会不足,而其他移植材料,如软骨/软骨膜或阔筋膜等,必须通过手术获取用于鼓膜成形术。在PRF鼓膜成形术中,PRF膜的制作次数没有上限,而且也无需为获取移植材料进行任何手术切口。贾巴尔普尔的尼塔吉·苏巴什·钱德拉·鲍斯医学院进行了一项涉及41名患者的前瞻性研究,在该研究中,使用PRF膜修复鼓膜穿孔,纳入研究的患者中有85.4%取得了成功结果。

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本文引用的文献

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The Benefits of Platelet-Rich Fibrin.富含血小板纤维蛋白的益处。
Facial Plast Surg Clin North Am. 2019 Aug;27(3):331-340. doi: 10.1016/j.fsc.2019.03.005.
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A study on outcome of underlay, overlay and combined techniques of myringoplasty.鼓膜成形术的内植法、外覆法及联合技术的疗效研究
Indian J Otolaryngol Head Neck Surg. 2012 Mar;64(1):63-6. doi: 10.1007/s12070-011-0257-z. Epub 2011 Jul 21.
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Repair of large traumatic tympanic membrane perforation with a Steri-Strips patch.应用 Steri-Strips 贴片修复外伤性大鼓膜穿孔
Otolaryngol Head Neck Surg. 2011 Oct;145(4):581-5. doi: 10.1177/0194599811409836. Epub 2011 May 18.

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