Department of Anesthesiology, LSU Health Shreveport, Shreveport, LA, USA.
Department of Anesthesiology, LSU Health New Orleans, New Orleans, LA, USA.
Adv Ther. 2020 Sep;37(9):3707-3722. doi: 10.1007/s12325-020-01453-4. Epub 2020 Jul 29.
Platelet diseases and dysfunction are taught early in medical school to all future physicians. Understanding of the coagulation cascade and hemostatic mechanisms has allowed for targeted pharmacological therapies that have been significantly impactful in clinical practice. Platelets are an early participant in hemostasis physiologically and under pathophysiological states.
A review of literature involving platelet disfunction.
Various presentations of platelet diseases and dysfunction challenge clinicians and require a firm understanding of normal platelet function, drugs that mediate or modulate platelet effectiveness, and nonpharmacologic etiologies of platelet diseases and dysfunction with corresponding best practice treatment approaches.
This review summarizes normal and abnormal states associated with platelets and treatment strategies.
血小板疾病和功能障碍在医学生早期就被教授给所有未来的医生。对凝血级联和止血机制的理解已经允许了靶向药理学治疗，这在临床实践中产生了重大影响。血小板在生理上和病理生理状态下都是止血的早期参与者。
对涉及血小板功能障碍的文献进行回顾。
各种血小板疾病和功能障碍的表现都对临床医生提出了挑战，需要对正常血小板功能、调节血小板作用的药物以及血小板疾病和功能障碍的非药理学病因有一个坚定的理解，并相应地采用最佳的治疗方法。
这篇综述总结了与血小板相关的正常和异常状态以及治疗策略。
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