Division of Internal Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Center of Aging, University of Connecticut Health Center, Farmington, Connecticut, USA.
J Dig Dis. 2020 Oct;21(10):583-592. doi: 10.1111/1751-2980.12926. Epub 2020 Sep 13.
To determine differences in frequencies of vaccine-preventable diseases between alcoholic liver disease (ALD) and non-alcoholic liver disease (NALD) patients.
This population-based cohort study used USA national inpatient sample ICD-9 codes from January 2012 to September 2015. Frequencies of admissions for ALD and NALD in patients with pneumococcal pneumonia, influenza, herpes zoster virus, varicella zoster virus, hepatitis A, hepatitis B, human papilloma virus, meningococcal meningitis, diphtheria, pertussis and tetanus were measured. Frequencies and patients' characteristics were compared for ALD and NALD using χ test and multivariate logistic regression analysis.
There was no difference in admissions for hepatitis A and pneumococcal pneumonia between the ALD and NALD groups. There were fewer admissions for hepatitis B (1.17% vs 1.80%, odds ratio [OR] 0.64, P < 0.01), herpes zoster (0.12% vs 0.17%, OR 0.69, P < 0.01), influenza (0.16% vs 0.26%, OR 0.59, P < 0.01) and all others (0.005% vs 0.015%, OR 0.36, P = 0.01) in the ALD group than the NALD group. The extreme all patient refined-diagnosis related groups mortality risk was 15.24% in ALD and 7.77% in NALD admissions (P < 0.0001).
The most frequent vaccine-preventable disease in both groups was hepatitis B. Patients with NALD had higher odds of admissions for hepatitis B, herpes zoster virus, influenza and other vaccine-preventable disease than ALD patients. However, the ALD group had a higher risk of mortality when admitted to hospital with a vaccine-preventable disease than the NALD group.
确定酒精性肝病 (ALD) 和非酒精性肝病 (NALD) 患者的疫苗可预防疾病的发病率差异。
本基于人群的队列研究使用了美国 2012 年 1 月至 2015 年 9 月期间的国家住院患者样本 ICD-9 代码。测量了肺炎球菌肺炎、流感、带状疱疹病毒、水痘带状疱疹病毒、甲型肝炎、乙型肝炎、人乳头瘤病毒、脑膜炎奈瑟菌脑膜炎、白喉、百日咳和破伤风患者中 ALD 和 NALD 的住院频率。使用 χ 检验和多变量逻辑回归分析比较了 ALD 和 NALD 患者的频率和患者特征。
在 ALD 和 NALD 组之间，甲型肝炎和肺炎球菌肺炎的住院率没有差异。乙型肝炎的住院率较低 (1.17% vs 1.80%，比值比 [OR] 0.64，P < 0.01)，带状疱疹 (0.12% vs 0.17%，OR 0.69，P < 0.01)、流感 (0.16% vs 0.26%，OR 0.59，P < 0.01) 和其他所有疾病 (0.005% vs 0.015%，OR 0.36，P = 0.01) 的住院率均低于 NALD 组。ALD 组的极端全患者精细化诊断相关组死亡率为 15.24%，NALD 组为 7.77%（P < 0.0001）。
两组最常见的疫苗可预防疾病是乙型肝炎。与 ALD 患者相比，NALD 患者更有可能因乙型肝炎、带状疱疹病毒、流感和其他疫苗可预防疾病住院。然而，当患有疫苗可预防疾病住院时，ALD 组的死亡率风险高于 NALD 组。
