Center of Liver Diseases Division 3, Beijing Ditan Hospital, Capital Medical University, 8 Jingshundong Street, Chaoyang District, Beijing, 100015, China.
Peking University Ditan Teaching Hospital, Beijing, 100015, China.
BMC Public Health. 2023 May 11;23(1):859. doi: 10.1186/s12889-023-15749-x.
Alcohol related liver disease (ARLD) is one of the major chronic liver diseases worldwide. This review aimed to describe the global prevalence, incidence, and outcomes of ARLD.
Medline, Embase, The Cochrane Library, and China National Knowledge Infrastructure (CNKI) were searched from inception to May 31, 2022. The language was restricted to English or Chinese. According to the criteria, articles describing the basic characteristics of the population were selected. Two reviewers extracted the data independently.
A total of 372 studies were identified: 353 were used for prevalence analysis, 7 were used for incidence analysis, and 114 were used to for outcome analysis. The prevalence of ARLD worldwide was 4.8%. The prevalence in males was 2.9%, which was higher than female (0.5%). Among the ethnic groups, the percentage was highest in Caucasians (68.9%). Alcoholic liver cirrhosis comprised the highest proportion in the disease spectrum of ARLD at 32.9%. The prevalence of ascites in ARLD population was highest (25.1%). The ARLD population who drinking for > 20 years accounted for 54.8%, and the average daily alcohol intake was 146.6 g/d. About 59.5% of ARLD patients were current or former smokers, and 18.7% were complicated with hepatitis virus infection. The incidence was 0.208/1000 person-years. The overall mortality was 23.9%, and the liver-related mortality was 21.6%.
The global prevalence of ARLD was 4.8% and was affected by sex, region, drinking years, and other factors. Therefore, removing the factors causing a high disease prevalence is an urgent requisite.
PROSPERO Nr: CRD42021286192.
酒精性肝病（ALD）是全球主要的慢性肝病之一。本综述旨在描述ALD 的全球流行率、发病率和结局。
从建库到 2022 年 5 月 31 日，我们在 Medline、Embase、The Cochrane Library 和中国国家知识基础设施（CNKI）中进行了检索。语言限制为英语或中文。根据标准，选择描述人群基本特征的文章。两名评审员独立提取数据。
共确定 372 项研究：353 项用于流行率分析，7 项用于发病率分析，114 项用于结局分析。全球 ALD 的流行率为 4.8%。男性的流行率为 2.9%，高于女性（0.5%）。在不同种族中，白种人所占比例最高（68.9%）。在 ALD 疾病谱中，酒精性肝硬化所占比例最高（32.9%）。ALD 人群中腹水的流行率最高（25.1%）。ALD 人群中饮酒时间>20 年者占 54.8%，平均日饮酒量为 146.6 g/d。约 59.5%的 ALD 患者为现患或曾患吸烟者，18.7%合并乙型肝炎病毒感染。发病率为 0.208/1000 人年。总体死亡率为 23.9%，肝相关死亡率为 21.6%。
ALD 的全球流行率为 4.8%，受性别、地区、饮酒年限等因素影响。因此，消除导致高疾病流行率的因素是当务之急。
PROSPERO 编号：CRD42021286192。
