CONACyT-Instituto de Neuroetología, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
IIIT Srikakulam, Rajiv Gandhi University of Knowledge Technologies (RGUKT), India.
Folia Neuropathol. 2020;58(2):113-122. doi: 10.5114/fn.2020.96755.
Lipopolysaccharide (LPS) is a potent immunogen when administered locally and/or systemically. The peripheral immunization with LPS could contribute to the progression of neurological diseases because a strong link between neuroinflammation and dopaminergic degeneration has been found. The switch between the survival and neuronal death in substantia nigra could be related to M1 (neurotoxic) and M2 (neuroprotective) microglia phenotypes. In this review, we present the current findings about microglia roles, biomarkers, and natural or synthetic immune modulators determined in the LPS-based murine model.
脂多糖（LPS）在局部和/或全身给药时是一种有效的免疫原。外周给予 LPS 会导致神经退行性疾病的进展，因为已经发现神经炎症和多巴胺能变性之间存在很强的联系。黑质中存活和神经元死亡之间的转变可能与 M1（神经毒性）和 M2（神经保护）小胶质细胞表型有关。在这篇综述中，我们介绍了基于 LPS 的小鼠模型中确定的小胶质细胞作用、生物标志物和天然或合成免疫调节剂的最新发现。
