Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.
East Maui Community Medicine, Hana, HI.
Parasitology. 2021 Feb;148(2):227-233. doi: 10.1017/S0031182020001262. Epub 2020 Jul 30.
A subcommittee of the Hawaii Governor's Joint Task Force on Rat Lungworm Disease developed preliminary guidelines for the diagnosis and treatment of neuroangiostrongyliasis (NAS) in 2018 (Guidelines, 2018). This paper reviews the main points of those guidelines and provides updates in areas where our understanding of the disease has increased. The diagnosis of NAS is described, including confirmation of infection by real-time polymerase chain reaction (RTi-PCR) to detect parasite DNA in the central nervous system (CNS). The treatment literature is reviewed with recommendations for the use of corticosteroids and the anthelminthic drug albendazole. Long-term sequelae of NAS are discussed and recommendations for future research are proposed.
2018 年，夏威夷州长联合工作队的一个小组委员会制定了神经血管旋毛虫病（NAS）诊断和治疗的初步指南（指南，2018 年）。本文回顾了这些指南的要点，并在我们对该疾病的认识有所提高的领域提供了更新。描述了 NAS 的诊断，包括通过实时聚合酶链反应（RTi-PCR）检测中枢神经系统（CNS）中寄生虫 DNA 来确认感染。本文还回顾了治疗文献，推荐使用皮质类固醇和驱虫药物阿苯达唑。讨论了 NAS 的长期后遗症，并提出了未来研究的建议。
