Zakharova N V, Zozulya S A, Sarmanova Z V, Bravve L V, Otman I N, Klyushnik T P
Alekseev Moscow Psychiatric Hospital No. 1, Moscow, Russia.
Mental Health Research Centre, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(6. Vyp. 2):46-53. doi: 10.17116/jnevro202012006246.
An analysis of inflammatory and autoimmune markers in schizophrenic patients with- and without catatonic symptoms in comparison to healthy controls.
A sample of 170 patients with paranoid schizophrenia was stratified by the presence of catatonic symptoms in the structure of psychosis (66 patients with catatonia and 104 patients without catatonia), inclusion threshold was >10 points on the Bush-Francis catatonia scale. The examination was carried out in the early days of inpatient treatment using psychopathological, psychometric and immunological methods.
Quantitative and qualitative differences in the spectrum of immune indicators in both groups of patients are revealed. A higher level of the immune system activation is found in the group with catatonic symptoms that indicates a worsening of the pathological process. A specific feature of the immunological profile of catatonic syndrome in schizophrenia is a decrease in ratio between leukocyte elastase and a1-proteinase inhibitor (leukocyte-inhibitory index) accompanied by the increase of other inflammatory markers that, presumably, indicates the deterioration of the phagocyte component of the inflammatory response.
The results suggest that the decrease in leukocyte-inhibitory index is a potential biomarker of catatonic syndrome in schizophrenia.
分析伴有和不伴有紧张症症状的精神分裂症患者与健康对照相比的炎症和自身免疫标志物。
将170例偏执型精神分裂症患者样本根据精神病结构中是否存在紧张症症状进行分层（66例有紧张症患者和104例无紧张症患者），纳入阈值为布什 - 弗朗西斯紧张症量表得分>10分。在住院治疗初期采用精神病理学、心理测量学和免疫学方法进行检查。
两组患者免疫指标谱存在定量和定性差异。在有紧张症症状的组中发现免疫系统激活水平较高，这表明病理过程恶化。精神分裂症紧张症综合征免疫特征的一个具体特点是白细胞弹性蛋白酶与α1 - 蛋白酶抑制剂的比率降低（白细胞抑制指数），同时其他炎症标志物增加，这可能表明炎症反应吞噬细胞成分的恶化。
结果表明白细胞抑制指数降低是精神分裂症紧张症综合征的潜在生物标志物。
