State Key Laboratory of Component-Based Chinese Medicine, Ministry of Education Key Laboratory of Pharmacology of Traditional Chinese Medicine Formulae, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Neuroscientist. 2021 Jun;27(3):235-245. doi: 10.1177/1073858420939034. Epub 2020 Jul 30.
Adult neurogenesis is a process that generates new and functional neurons from neural stem cells (NSCs) in a specialized neurogenic niche throughout life. Misregulated neurogenesis is detrimental to normal brain functions. To ensure proper neurogenesis, the niche cells must respond to extrinsic cues while fulfilling the intrinsic requirements of the neurogenic program and adapting their roles accordingly to influence NSC behavior. Understanding how the neurogenic niche executes its functions may guide strategies to maintain its integrative process and provide a permissive milieu for neurogenesis. In this review, we summarize the recent discoveries of interactive regulation of NSCs and neurogenesis by neurogenic niche and its implications in functional integrity of adult brain and neurological disorders.
成人神经发生是一个过程，即在整个生命过程中，从神经干细胞（NSC）中产生新的和功能性的神经元。神经发生的失调对正常的大脑功能是有害的。为了确保适当的神经发生，小生境细胞必须对外界线索做出反应，同时满足神经发生程序的内在要求，并相应地调整其角色，以影响 NSC 的行为。了解神经发生小生境如何执行其功能，可以指导维持其整合过程的策略，并为神经发生提供一个许可的环境。在这篇综述中，我们总结了神经发生小生境对 NSCs 和神经发生的相互调节的最新发现及其对成年大脑功能完整性和神经障碍的影响。
