Bovier P, Pringuey D, Widmer J, Chiaroni P, Gaillard J M, Dufour H, Tissot R
Département de psychiatrie, Institutions universitaires de Psychiatrie, Genève, Suisse.
Acta Psychiatr Belg. 1988 Jul-Aug;88(4):303-12.
The present study concerned 69 depressed patients (26 men, 43 women). The antidepressant drug was prescribed in accordance with perturbations of tyrosine and tryptophan membrane transports (MT) across the red cell, measured in vitro after a wash-out period of ten days. After two to four months of treatment, the clinical results were divided into two groups: normal mood (AMDP - Depression Scale less than 6) and no recovery (AMDP - Depression Scale greater than 6). The initial criteria (e.g. MT) was completed by using plasma tyrosine, tryptophan and the product MT by plasma level. Indeed, the success of this treatment was corresponding to precise abnormalities of variable: (i) tyrosine and tryptophan values for imipramine, (ii) tyrosine values, plasma tryptophan and tryptophan product for desipramine, (iii) tryptophan variables and plasma tyrosine for fluvoxamine (and indalpine). The analysis of clinical failures permitted to complete our previous choice of antidepressant drug.
本研究涉及69名抑郁症患者（26名男性，43名女性）。在经过10天的洗脱期后，于体外测量红细胞中酪氨酸和色氨酸膜转运（MT）的扰动情况，并据此开具抗抑郁药物。经过两到四个月的治疗，临床结果分为两组：情绪正常（AMDP - 抑郁量表得分低于6）和未康复（AMDP - 抑郁量表得分高于6）。通过血浆酪氨酸、色氨酸以及血浆水平的MT乘积来完善初始标准（如MT）。实际上，这种治疗的成功与多种变量的精确异常情况相对应：（i）丙咪嗪的酪氨酸和色氨酸值，（ii）去甲丙咪嗪的酪氨酸值、血浆色氨酸和色氨酸乘积，（iii）氟伏沙明（以及茚达品）的色氨酸变量和血浆酪氨酸。对临床治疗失败情况的分析有助于完善我们之前对抗抑郁药物的选择。
