Price Institute of Surgical Research, Department of Surgery, University of Louisville , Louisville, KY, USA.
Cancer Biol Ther. 2020 Sep 1;21(9):769-781. doi: 10.1080/15384047.2020.1794239. Epub 2020 Jul 30.
Colorectal cancer (CRC) is a leading cause of cancer-related death. Epithelial-mesenchymal transition (EMT) is a major process in tumor metastasis development. This systematic review aims to describe the role of long non-coding RNA (lncRNA) in EMT in CRC.
The electronic databases, PubMed, Cochrane, and EMBASE, were searched from January1990 to June 2019 to identify studies examining lncRNA and their role in mediating EMT in CRC. Studies examining clinical specimens and/or in vitro experiments were included.
In 61 identified studies, 54 lncRNAs were increased in CRC compared to normal colorectal epithelium. Increased lncRNA expression was frequently associated with worse survival. Many lncRNAs mediate their effect through competitive endogenous RNA or transcription factor regulation. The ZEB1, 2/E-cadherin, Wnt/β-catenin signaling, and chromatin remodeling pathways are discussed in particular.
lncRNAs are major regulators of EMT and predictor adverse outcome in CRC patients. Future research must focus on delineating lncRNA function prior to potential clinical use.
结直肠癌（CRC）是癌症相关死亡的主要原因。上皮-间充质转化（EMT）是肿瘤转移发展的主要过程。本系统评价旨在描述长链非编码 RNA（lncRNA）在 CRC 中的 EMT 中的作用。
从 1990 年 1 月至 2019 年 6 月，我们在电子数据库 PubMed、Cochrane 和 EMBASE 中搜索了研究 lncRNA 及其在 CRC 中调节 EMT 作用的研究。纳入了研究临床标本和/或体外实验的研究。
在 61 项已确定的研究中，54 种 lncRNA 在 CRC 中比正常结直肠上皮增加。lncRNA 表达增加常与生存不良有关。许多 lncRNA 通过竞争性内源性 RNA 或转录因子调节来发挥其作用。特别讨论了 ZEB1、2/E-钙黏蛋白、Wnt/β-连环蛋白信号通路和染色质重塑途径。
lncRNA 是 EMT 的主要调节剂，也是 CRC 患者不良预后的预测因子。未来的研究必须集中在描绘 lncRNA 功能之前，然后才能进行潜在的临床应用。
