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通过与IGF2BP1结合以增强结缔组织生长因子mRNA的稳定性来促进结直肠癌的恶性进展。

promotes colorectal cancer malignant progression by binding with IGF2BP1 to enhance the stability of connective tissue growth factor mRNA.

作者信息

Lun Weijian, Zhang Xiaobin, Hong Yinsheng, Luo Canhua, Liu Yongjia

机构信息

Department of Gastroenterology, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, 528200, Guangdong Province, P.R. China.

Department of Internal Medicine, Foshan Women & Children Hospital, Foshan, 528200, Guangdong Province, P.R. China.

出版信息

Epigenomics. 2024;16(14):985-998. doi: 10.1080/17501911.2024.2373686. Epub 2024 Jul 29.

DOI:10.1080/17501911.2024.2373686
PMID:39072366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11404617/
Abstract

This study aimed to investigate the role of in colorectal cancer (CRC) progression. Cell proliferation was evaluated using Cell Counting Kit-8. Cell migration was detected with transwell assay. RNA pull-down was applied for verifying the interactions between , IGF2BP1 and connective tissue growth factor (). , IGF2BP1 and levels were upregulated in CRC. Knockdown of significantly inhibited the malignant behavior of CRC cells. increased mRNA stability by binding with IGF2BP1. Furthermore, overexpression of IGF2BP1 or reversed the inhibitory effect of shRNA on CRC progression. promoted CRC cell malignant behaviors through IGF2BP1/.

摘要

本研究旨在探讨[未提及具体内容]在结直肠癌（CRC）进展中的作用。使用细胞计数试剂盒-8评估细胞增殖。采用Transwell实验检测细胞迁移。应用RNA下拉实验验证[未提及具体内容]、IGF2BP1与结缔组织生长因子（[未提及具体内容]）之间的相互作用。[未提及具体内容]、IGF2BP1和[未提及具体内容]水平在CRC中上调。敲低[未提及具体内容]显著抑制CRC细胞的恶性行为。[未提及具体内容]通过与IGF2BP1结合增加[未提及具体内容]mRNA稳定性。此外，IGF2BP1或[未提及具体内容]的过表达逆转了[未提及具体内容] shRNA对CRC进展的抑制作用。[未提及具体内容]通过IGF2BP1/[未提及具体内容]促进CRC细胞的恶性行为。

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