Pérez de Arce Edith, Sedano Rocío, Quera Rodrigo
Departamento de Medicina Interna, Servicio de Gastroenterología, Hospital Clínico Universidad de Chile, Santiago, Chile.
Programa Enfermedad Inflamatoria Intestinal, Servicio de Gastroenterología, Clínica Las Condes, Santiago, Chile.
Rev Med Chil. 2020 Mar;148(3):362-370. doi: 10.4067/S0034-98872020000300362.
Biomarkers in inflammatory bowel disease are an essential tool in clinical practice. They allow a non-invasive evaluation of patients and thus guide decision-making at different stages of the disease, including diagnostic suspicion, severity assessment, relapse prediction, and treatment response. Although biomarkers in blood such as erythrocyte sedimentation rate and C-reactive protein, are the most commonly used biomarkers, because their low cost and accessibility, they lack specificity. Currently, fecal biomarkers offer greater reliability, applicability, and specificity. Fecal calprotectin is the most commonly used marker. This review discusses the advantages and disadvantages of biomarkers in inflammatory bowel disease, as well as their clinical applications and new biomarkers currently under research.
炎症性肠病中的生物标志物是临床实践中的重要工具。它们可对患者进行非侵入性评估,从而在疾病的不同阶段指导决策,包括诊断怀疑、严重程度评估、复发预测和治疗反应。尽管血液中的生物标志物如红细胞沉降率和C反应蛋白是最常用的生物标志物,因其成本低且易于获取,但它们缺乏特异性。目前,粪便生物标志物具有更高的可靠性、适用性和特异性。粪便钙卫蛋白是最常用的标志物。本文综述了炎症性肠病中生物标志物的优缺点、临床应用以及目前正在研究的新生物标志物。