Relative efficiencies of a series of square-planar plantinum(II) compounds on Salmonella mutagenesis.
作者信息
Lecointe P, Macquet J P, Butour J L, Paoletti C
出版信息
Mutat Res. 1977 Apr;48(2):139-43. doi: 10.1016/0027-5107(77)90153-1.
PMID:327304
Abstract
Twelve Pt(II) compounds have been tested for mutagenicity on Salmonella typhimurium (strain TA 100). Very high mutagenic activities were found for the cis derivatives. A correlation is suggested between these results and a formerly described model of chemical reactivity towards DNA, according to which cis derivatives from intra-strand chelates with guanine. A smaller activity was found with monodentate complexes with DNA.
摘要
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