Gajardo-Navarrete Jorge, Ibieta Guillermo, Concha Marco, Garcés Pamela, Robles Isabel, Vera-Calzaretta Aldo, González-Burboa Alexis, Gajardo Ignacio, Gutiérrez Milenka, Villarroel Mauricio, Aguayo Matías
Departamento de Medicina Interna, Facultad de Medicina, Universidad de Concepción, Concepción, Chile.
Unidad de Hemodinamia, Centro Cardiovascular, Hospital Guillermo Grant Benavente, Concepción, Chile.
Rev Med Chil. 2020 Feb;148(2):145-150. doi: 10.4067/s0034-98872020000200145.
Postmenopausal women have higher severity of coronary heart disease (CHD) than premenopausal women and type 2 diabetes mellitus (T2DM) is an independent risk factor.
To assess the severity of CHD in pre and postmenopausal patients undergoing coronary angiography and the impact of T2DM in both groups.
A coronary angiography was performed to 707 women due to suspected CHD during 2013 and 2014. Of these, 579 were older than 55 years and were considered as postmenopausal. Factors such as hypertension, obesity, smoking, creatinine and T2DM were registered. The severity of CHD in coronary angiography was evaluated according to the number of vessels with more than 50% stenosis.
Compared to their postmenopausal counterparts, premenopausal women had less frequency of T2DM (31% and 42% p < 0.033), hypertension (52 and 78%, p < 0.001) and alteration of renal function (11 vs. 39%, p < 0.001). Absence of coronary lesions was found in 44 and 32% of premenopausal and postmenopausal women, respectively (p < 0.01). Premenopausal women with T2DM had a higher frequency of multi-vessel disease than those without the disease (25 and 4.5%, p < 0.001). The frequency of multi-vessel disease was higher in postmenopausal than premenopausal women (24 and 11%, p < 0.01). Hypertension, T2DM and renal involvement were associated with a higher frequency multiple vessel disease.
The severity of CHD is higher in postmenopausal women and T2DM is associated with the disease.
绝经后女性冠心病（CHD）的严重程度高于绝经前女性，2型糖尿病（T2DM）是一个独立危险因素。
评估接受冠状动脉造影的绝经前和绝经后患者冠心病的严重程度以及T2DM在两组中的影响。
2013年至2014年期间，对707名疑似冠心病的女性进行了冠状动脉造影。其中，579名年龄超过55岁，被视为绝经后女性。记录了高血压、肥胖、吸烟、肌酐和T2DM等因素。根据狭窄超过50%的血管数量评估冠状动脉造影中冠心病的严重程度。
与绝经后女性相比，绝经前女性T2DM的发生率较低（31%和42%，p<0.033）、高血压（52%和78%，p<0.001）以及肾功能改变（11%对39%，p<0.001）。绝经前和绝经后女性分别有44%和32%未发现冠状动脉病变（p<0.01）。患有T2DM的绝经前女性多支血管病变的发生率高于未患该病的女性（25%和4.5%，p<0.001）。绝经后女性多支血管病变的发生率高于绝经前女性（24%和11%，p<0.01）。高血压、T2DM和肾脏受累与多支血管病变的较高发生率相关。
绝经后女性冠心病的严重程度更高，T2DM与该病相关。
