甲基化扩展了液体活检在癌症检测中的应用范围。
Methylation extends the reach of liquid biopsy in cancer detection.
机构信息
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.
出版信息
Nat Rev Clin Oncol. 2020 Nov;17(11):655-656. doi: 10.1038/s41571-020-0420-0.
Abstract
Measuring the methylation status of cell-free DNA (cfDNA) in plasma holds great potential for the early, noninvasive detection of cancer. Two recent papers published in Nature Medicine showcase the successful application of cfDNA methylation- based cancer detection to two highly challenging scenarios.
摘要
检测血浆中游离 DNA（cfDNA）的甲基化状态在癌症的早期、非侵入性检测方面具有巨大的潜力。最近在《自然医学》杂志上发表的两篇论文展示了基于 cfDNA 甲基化的癌症检测在两种极具挑战性的情况下的成功应用。
相似文献
1
Methylation extends the reach of liquid biopsy in cancer detection.甲基化扩展了液体活检在癌症检测中的应用范围。
Nat Rev Clin Oncol. 2020 Nov;17(11):655-656. doi: 10.1038/s41571-020-0420-0.
2
Using methylation signatures on cell-free DNA for early cancer detection: a new era in liquid biopsy?利用游离DNA的甲基化特征进行癌症早期检测：液体活检的新时代？
Ann Oncol. 2020 Jun;31(6):665-667. doi: 10.1016/j.annonc.2020.03.307. Epub 2020 Apr 11.
3
Blood Test Catches Cancers That Shed Little DNA.血液检测可捕捉到少量释放 DNA 的癌症。
Cancer Discov. 2020 Sep;10(9):1246-1247. doi: 10.1158/2159-8290.CD-NB2020-068. Epub 2020 Jul 14.
4
Liquid biopsies: DNA methylation analyses in circulating cell-free DNA.液体活检：循环无细胞 DNA 中的 DNA 甲基化分析。
J Genet Genomics. 2018 Apr 20;45(4):185-192. doi: 10.1016/j.jgg.2018.02.007. Epub 2018 Mar 8.
5
New warning signs on the road: 5-hydroxymethylcytosine-based liquid biopsy for the early detection of hepatocellular carcinoma.道路上的新警示信号：基于5-羟甲基胞嘧啶的液体活检用于肝细胞癌的早期检测。
Gut. 2019 Dec;68(12):2103-2104. doi: 10.1136/gutjnl-2019-319339. Epub 2019 Aug 7.
6
Meeting the high expectations for liquid biopsy assays for pediatric brain tumors: Progress and challenges.满足小儿脑肿瘤液体活检检测的高期望：进展与挑战。
Neuro Oncol. 2022 Aug 1;24(8):1364-1365. doi: 10.1093/neuonc/noac083.
7
Liquid biopsy: still early days for early detection.液体活检：早期检测仍处于起步阶段。
Lancet. 2018 Jun 30;391(10140):2593-2594. doi: 10.1016/S0140-6736(18)31476-4.
8
Epigenetic regulation by DNA methylation and miRNA molecules in cancer.DNA甲基化和微小RNA分子在癌症中的表观遗传调控
Future Oncol. 2017 Oct;13(25):2217-2222. doi: 10.2217/fon-2017-0363. Epub 2017 Oct 4.
9
Follow the trace of death: methylation analysis of cell-free DNA for clinical applications in non-cancerous diseases.追踪死亡轨迹：游离DNA甲基化分析在非癌性疾病临床应用中的研究
Epigenomics. 2016 Sep;8(9):1169-72. doi: 10.2217/epi-2016-0080. Epub 2016 Aug 16.
10
Liquid biopsy: A new avenue in pathology.液体活检：病理学的一条新途径。
Cytopathology. 2019 Mar;30(2):138-143. doi: 10.1111/cyt.12661. Epub 2019 Jan 11.
引用本文的文献
1
Unraveling the hidden complexity of cancer through long-read sequencing.通过长读长测序揭示癌症隐藏的复杂性。
Genome Res. 2025 Apr 14;35(4):599-620. doi: 10.1101/gr.280041.124.
2
The wedish initiative for the stdy of ary sclerosing cholangitis (SUPRIM).瑞典原发性硬化性胆管炎研究倡议（SUPRIM） 。
不过你提供的原文中“wedish”应是“Swedish”，“stdy”应是“study”，“ary”应是“primary”，可能存在一些拼写错误。
EClinicalMedicine. 2024 Mar 11;70:102526. doi: 10.1016/j.eclinm.2024.102526. eCollection 2024 Apr.
3
Microarray-Based DNA Methylation Profiling: Validation Considerations for Clinical Testing.基于微阵列的 DNA 甲基化分析：临床检测的验证考虑因素。
J Mol Diagn. 2024 Jun;26(6):447-455. doi: 10.1016/j.jmoldx.2024.02.001. Epub 2024 Feb 18.
4
The fragmentomic property of plasma cell-free DNA enables the non-invasive detection of diabetic nephropathy in patients with diabetes mellitus.血浆无细胞游离 DNA 的片段组学特性使得可以在糖尿病患者中无创检测糖尿病肾病。
Front Endocrinol (Lausanne). 2023 Oct 5;14:1164822. doi: 10.3389/fendo.2023.1164822. eCollection 2023.
5
CuH-Catalyzed Selective N-Methylation of Amines Using Paraformaldehyde as a C1 Source.以多聚甲醛为C1源的铜氢催化胺的选择性N-甲基化反应
ACS Omega. 2023 Aug 9;8(33):30640-30645. doi: 10.1021/acsomega.3c04332. eCollection 2023 Aug 22.
6
Advances in methylation analysis of liquid biopsy in early cancer detection of colorectal and lung cancer.液体活检中甲基化分析在结直肠癌和肺癌早期检测中的进展。
Sci Rep. 2023 Aug 19;13(1):13502. doi: 10.1038/s41598-023-40611-w.
7
erarchical tumor artificial intelligence classifier traces tissue of origin and tumor type in primary and metastasized tumors using DNA methylation.分层肿瘤人工智能分类器利用DNA甲基化追踪原发性和转移性肿瘤的组织起源和肿瘤类型。
NAR Cancer. 2023 Apr 19;5(2):zcad017. doi: 10.1093/narcan/zcad017. eCollection 2023 Jun.
8
Longitudinal monitoring of cell-free DNA methylation in ALK-positive non-small cell lung cancer patients.ALK 阳性非小细胞肺癌患者循环游离 DNA 甲基化的纵向监测。
Clin Epigenetics. 2022 Dec 2;14(1):163. doi: 10.1186/s13148-022-01387-4.
9
Kidney tumors associated with germline mutations of FH and SDHB show a CpG island methylator phenotype (CIMP).与 FH 和 SDHB 种系突变相关的肾肿瘤表现出 CpG 岛甲基化表型（CIMP）。
PLoS One. 2022 Dec 1;17(12):e0278108. doi: 10.1371/journal.pone.0278108. eCollection 2022.
10
Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma.全基因组异常 DNA 甲基化的多组学特征分析揭示了食管鳞癌的诊断和预后标志物。
Signal Transduct Target Ther. 2022 Feb 25;7(1):53. doi: 10.1038/s41392-022-00873-8.
Zotero 插件