Department of Radiology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.
Department of Radiology, Klinikum rechts der Isar der TU München, Ismaninger Straße 22, 81675, Munich, Germany.
Sci Rep. 2020 Jul 30;10(1):12889. doi: 10.1038/s41598-020-69819-w.
Adjacent to hepatic metastases, liver parenchyma is often histopathologically altered even if its visual appearance on native magnetic resonance (MR) images is blunt. Yet, relaxation properties in MR imaging may show structural changes prior to visual alteration, and therefore, the aim of this study was to investigate whether T1 relaxation times in the perilesional zone differ between metastases and benign lesions. A total of 113 patients referred for MRI were included prospectively. Images were assessed for metastases, solid benign lesions and cysts, and regions-of-interest were drawn on T1 maps including the focal lesion and a close (inner perilesional zone = IPZ) and a larger perilesional zone (outer perilesional zone = OPZ). Simple ratios between these zones, as well as a gradient ratio between the IPZ and the entire perilesional zone (EPZ) were calculated. Within the collective, 44 patients had lesions of one or two entities. For metastases, the simple ratio between IPZ and OPZ as well as the mean EPZ gradient was significantly higher than for both solid benign lesions and cysts. Lesion size was not a significant covariate. We conclude, that native T1 properties of the perilesional zones differ significantly between malignant and both solid and cystic benign lesions.
毗邻肝转移灶的肝实质组织，即便其在磁共振成像（MRI）原始图像上的外观表现正常，在组织病理学上也常常发生改变。然而，在形态学改变之前，MRI 成像的弛豫特性可能已经显示出结构变化，因此，本研究旨在探讨病灶周围区域的 T1 弛豫时间在转移灶和良性病变之间是否存在差异。
本研究前瞻性纳入了 113 例因 MRI 检查而转诊的患者。对转移灶、实性良性病变和囊肿进行图像评估，并在 T1 图谱上绘制病灶区域、紧邻病灶的（内病灶周围区=IPZ）和较大的病灶周围区（外病灶周围区=OPZ）的感兴趣区。计算这些区域之间的简单比值，以及 IPZ 和整个病灶周围区（EPZ）之间的梯度比。
在这组患者中，44 例患者有一个或两个病灶。对于转移灶，IPZ 和 OPZ 之间的简单比值以及平均 EPZ 梯度显著高于实性良性病变和囊肿。病灶大小不是显著的协变量。
我们得出结论，病灶周围区的原始 T1 特性在恶性肿瘤与实性和囊性良性病变之间存在显著差异。
