From the Departments of Radiology (J.K., H.P., D.G.), Radiation Medicine (I.G.S., T.D.), and Neuroradiology (C.B., T.L.), Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany; and Department of Diagnostic and Interventional Radiology, Philipps-University Marburg, Berlin, Germany (D.G.).
Radiology. 2017 Mar;282(3):708-716. doi: 10.1148/radiol.2016162535. Epub 2017 Jan 11.
Purpose To evaluate whether there is T1-weighted signal intensity (SI) increase in the dentate nucleus (DN) and globus pallidus (GP) in relation to the middle cerebellar peduncle (MCP), pons, and thalamus after repeated administration of the liver-specific contrast agent gadoxetic acid. Materials and Methods This was an institutional review board-approved, prospectively conducted (written informed consent acquired), cross-sectional study performed in a consecutively selected patient group (n = 91; patients received one to 37 doses of gadoxetic acid) and a control group (n = 52; subjects had never received injections of gadolinium-based contrast agent) examined with a standard T1-weighted two-dimensional spin-echo pulse sequence of the brain at 1.5 T. DN/MCP, DN-to-pons, GP-to thalamus, and GP-to-cerebrospinal fluid ratios were measured and compared by using the nonparametric Kruskal-Wallis test, corresponding pairwise tests, and Spearman correlation. Results DN/MCP (ρ = 0.51, P < .0001) and DN-to-pons (ρ = 0.41, P = .0001) ratios correlated positively with the number of previous administrations of gadoxetic acid. DN/MCP and DN-to-pons ratios were significantly different between control subjects (medians of 1.016 and 1.034, respectively) and patients with more than 10 gadoxetic acid administrations (1.038 [P < .0001] and 1.053 [P = .0100], respectively), whereas no significant difference was found in the groups with five to 10 (1.029 [P = .053] and 1.044 [P = .072], respectively) and fewer than five (1.014 [P = .420] and 1.030 [P = .595], respectively) gadoxetic acid administrations. GP-to-thalamus ratios differed significantly between the study and control groups (P < .0001), whereas no significant correlation was found for GP-to-thalamus ratios and number of gadoxetic acid administrations (ρ = 0.13, P = .2304). Conclusion Results show a significant correlation between the number of gadoxetic acid administrations and the increase of SI in the DN, which is likely due to gadolinium retention. RSNA, 2017.
目的 评估重复使用肝特异性对比剂钆塞酸后，齿状核（DN）和苍白球（GP）相对于中脑小脑脚（MCP）、脑桥和丘脑的 T1 加权信号强度（SI）是否增加。
材料与方法 这是一项机构审查委员会批准的前瞻性研究（获得书面知情同意），对连续选择的患者组（n=91；患者接受 1 至 37 次钆塞酸注射）和对照组（n=52；受试者从未接受过含钆对比剂注射）进行了横断面研究，使用标准的 1.5 T 磁共振成像脑 T1 加权二维自旋回波脉冲序列进行检查。通过使用非参数 Kruskal-Wallis 检验、相应的配对检验和 Spearman 相关性，测量并比较了 DN/MCP、DN 与脑桥、GP 与丘脑以及 GP 与脑脊液的比值。
结果 DN/MCP（ρ=0.51，P<0.0001）和 DN 与脑桥的比值（ρ=0.41，P=0.0001）与钆塞酸的使用次数呈正相关。DN/MCP 和 DN 与脑桥的比值在对照组（中位数分别为 1.016 和 1.034）和接受超过 10 次钆塞酸治疗的患者之间存在显著差异（1.038[P<0.0001]和 1.053[P=0.0100]），而在接受 5 至 10 次（1.029[P=0.053]和 1.044[P=0.072]）和少于 5 次（1.014[P=0.420]和 1.030[P=0.595]）钆塞酸治疗的患者之间无显著差异。GP 与丘脑的比值在研究组和对照组之间存在显著差异（P<0.0001），而 GP 与丘脑的比值与钆塞酸的使用次数之间无显著相关性（ρ=0.13，P=0.2304）。
结论 结果表明，钆塞酸的使用次数与 DN 中 SI 的增加之间存在显著相关性，这可能是由于钆的蓄积所致。
放射学协会，2017 年。
