氯氮平在综合医院的应用。
Use of Clozapine in the General Hospital.
机构信息
Mustafa, MD, Department of Liaison Psychiatry, Northampton General Hospital, Northampton, United Kingdom.
出版信息
Psychopharmacol Bull. 2020 Jul 23;50(3):119-124.
Abstract
Patients with treatment-resistant schizophrenia receiving clozapine therapy are at risk of potentially serious complications in the general hospital setting, due to the complex pharmacokinetic and pharmacodynamic profile of clozapine. We summarize common clinical challenges that face clinicians who care for clozapine patients in the general hospital, and make recommendations based on the available literature and clinical experience. Early collaborative management between consultation-liaison psychiatry and other clinical teams in the general hospital is paramount to improve clinical outcomes and avoid serious complications in this patient group.
摘要
接受氯氮平治疗的治疗抵抗性精神分裂症患者由于氯氮平复杂的药代动力学和药效学特征，在综合医院环境中存在潜在严重并发症的风险。我们总结了在综合医院照顾氯氮平患者的临床医生所面临的常见临床挑战，并根据现有文献和临床经验提出建议。咨询-联络精神病学与综合医院其他临床团队之间的早期协作管理对于改善该患者群体的临床结果并避免严重并发症至关重要。
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本文引用的文献
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Around 3% of 1,300 Levels Were Elevated during Infections in a Retrospective Review of 131 Beijing Hospital In-Patients with More than 24,000 Days of Clozapine Treatment.在一项对131名北京医院住院患者进行的回顾性研究中，这些患者接受了超过24000天的氯氮平治疗，在感染期间，1300个检测指标中约3%出现升高。
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Clinical and laboratory characteristics of clozapine-treated patients with schizophrenia referred to a national immunodeficiency clinic reveals a B-cell signature resembling common variable immunodeficiency (CVID).就诊于国家免疫缺陷诊所的接受氯氮平治疗的精神分裂症患者的临床和实验室特征显示出类似于普通可变免疫缺陷 (CVID) 的 B 细胞特征。
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Patient characteristics, burden and pharmacotherapy of treatment-resistant schizophrenia: results from a survey of 204 US psychiatrists.治疗抵抗性精神分裂症患者的特征、负担和药物治疗：来自对 204 名美国精神科医生的调查结果。
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Closure beyond clozapine: successfully averting rebound symptoms in a patient with schizoaffective disorder and agranulocytosis.氯氮平之外的治疗：成功避免一位精神分裂症伴情感障碍和粒细胞缺乏症患者的戒断症状
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