Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil.
Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Front Immunol. 2020 Jul 7;11:1672. doi: 10.3389/fimmu.2020.01672. eCollection 2020.
Pregnancy comprises a unique immunological condition, to allow fetal development and to protect the host from pathogenic infections. Viral infections during pregnancy can disrupt immunological tolerance and may generate deleterious effects on the fetus. Despite these possible links between pregnancy and infection-induced morbidity, it is unclear how pregnancy interferes with maternal response to some viral pathogens. In this context, the novel coronavirus (SARS-CoV-2) can induce the coronavirus diseases-2019 (COVID-19) in pregnant women. The potential risk of vertical transmission is unclear, babies born from COVID-19-positive mothers seems to have no serious clinical symptoms, the possible mechanisms are discussed, which highlights that checking the children's outcome and more research is warranted. In this review, we investigate the reports concerning viral infections and COVID-19 during pregnancy, to establish a correlation and possible implications of COVID-19 during pregnancy and neonatal's health.
妊娠是一种独特的免疫状态，既能允许胎儿发育，又能保护宿主免受病原感染。妊娠期间的病毒感染可破坏免疫耐受，并可能对胎儿产生有害影响。尽管妊娠与感染引起的发病率之间可能存在这些联系，但目前尚不清楚妊娠如何干扰母体对某些病毒病原体的反应。在这种情况下，新型冠状病毒（SARS-CoV-2）可引发妊娠妇女的 2019 年冠状病毒病（COVID-19）。垂直传播的潜在风险尚不清楚，来自 COVID-19 阳性母亲的婴儿似乎没有严重的临床症状，讨论了可能的机制，这表明需要检查儿童的结果并进行更多的研究。在这篇综述中，我们调查了与妊娠期间病毒感染和 COVID-19 相关的报告，以确定 COVID-19 与妊娠和新生儿健康之间的相关性和可能的影响。
