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Commentary: Dietary methionine influences therapy in mouse cancer models and alters human metabolism.

作者信息

Abid Muhammad Abbas, Abid Muhammad Bilal

机构信息

Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Divisions of Hematology/Oncology & Infectious Diseases, Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, United States.

出版信息

Front Oncol. 2020 Jul 6;10:1071. doi: 10.3389/fonc.2020.01071. eCollection 2020.

DOI:10.3389/fonc.2020.01071
PMID:32733800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7357428/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f1/7357428/318ba99f9282/fonc-10-01071-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f1/7357428/318ba99f9282/fonc-10-01071-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0f1/7357428/318ba99f9282/fonc-10-01071-g0001.jpg

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Exp Hematol Oncol. 2019 Nov 19;8:31. doi: 10.1186/s40164-019-0155-8. eCollection 2019.
2
Probiotics in health and disease: fooling Mother Nature?益生菌在健康与疾病中的作用：欺骗大自然？
Infection. 2019 Dec;47(6):911-917. doi: 10.1007/s15010-019-01351-0. Epub 2019 Sep 2.
3
Dietary methionine influences therapy in mouse cancer models and alters human metabolism.膳食蛋氨酸影响小鼠癌症模型的治疗并改变人体代谢。
Nature. 2019 Aug;572(7769):397-401. doi: 10.1038/s41586-019-1437-3. Epub 2019 Jul 31.
4
Methionine is a metabolic dependency of tumor-initiating cells.蛋氨酸是肿瘤起始细胞的代谢依赖性物质。
Nat Med. 2019 May;25(5):825-837. doi: 10.1038/s41591-019-0423-5. Epub 2019 May 6.
5
Could the menagerie of the gut microbiome really cure cancer? Hope or hype.肠道微生物群的大千世界真能治愈癌症吗？希望还是炒作。
J Immunother Cancer. 2019 Apr 2;7(1):92. doi: 10.1186/s40425-019-0561-9.
6
Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models.在胰腺癌和黑色素瘤患者来源的原位异种移植（PDOX）裸鼠模型中，肿瘤内L-蛋氨酸水平与肿瘤大小高度相关。
Oncotarget. 2018 Jan 17;9(13):11119-11125. doi: 10.18632/oncotarget.24264. eCollection 2018 Feb 16.
7
Review article: insights into colonic protein fermentation, its modulation and potential health implications.综述文章：对结肠蛋白质发酵、其调节及其潜在健康影响的见解。
Aliment Pharmacol Ther. 2016 Jan;43(2):181-96. doi: 10.1111/apt.13456. Epub 2015 Nov 2.
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Selective methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity.通过FUCCI成像观察到，甲硫氨酸酶选择性诱导癌细胞滞留在S/G2期可赋予化疗敏感性。
Oncotarget. 2014 Sep 30;5(18):8729-36. doi: 10.18632/oncotarget.2369.
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Dietary methionine restriction with FOLFOX regimen as first line therapy of metastatic colorectal cancer: a feasibility study.饮食限制蛋氨酸联合 FOLFOX 方案一线治疗转移性结直肠癌：一项可行性研究。
Oncology. 2010;78(3-4):205-9. doi: 10.1159/000313700. Epub 2010 Apr 26.
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Amino Acids. 2010 Jul;39(2):335-47. doi: 10.1007/s00726-009-0445-2. Epub 2009 Dec 18.