信号转导与转录激活因子3（STAT3）促进癌症的放射抗性。
STAT3 Contributes to Radioresistance in Cancer.
作者信息
Wang Xuehai, Zhang Xin, Qiu Chen, Yang Ning
机构信息
Department of Otolaryngology, Weihai Municipal Hospital, Shandong University, Weihai, China.
Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, China.
出版信息
Front Oncol. 2020 Jul 7;10:1120. doi: 10.3389/fonc.2020.01120. eCollection 2020.
Abstract
Radiotherapy has been used in the clinic for more than one century and it is recognized as one of the main methods in the treatment of malignant tumors. Signal Transducers and Activators of Transcription 3 (STAT3) is reported to be upregulated in many tumor types, and it is believed to be involved in the tumorigenesis, development and malignant behaviors of tumors. Previous studies also found that STAT3 contributes to chemo-resistance of various tumor types. Recently, many studies reported that STAT3 is involved in the response of tumor cells to radiotherapy. But until now, the role of the STAT3 in radioresistance has not been systematically demonstrated. In this study, we will review the radioresistance induced by STAT3 and relative solutions will be discussed.
摘要
放射疗法在临床上已应用了一个多世纪，它被公认为是治疗恶性肿瘤的主要方法之一。据报道，信号转导子和转录激活子3（STAT3）在多种肿瘤类型中上调，并且被认为参与肿瘤的发生、发展和恶性行为。先前的研究还发现STAT3促成了各种肿瘤类型的化疗耐药性。最近，许多研究报道STAT3参与肿瘤细胞对放射疗法的反应。但直到现在，STAT3在放射抗性中的作用尚未得到系统的证实。在本研究中，我们将综述由STAT3诱导的放射抗性，并讨论相关的解决方案。
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