Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Department of Chemistry, Science Faculty, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh.
Front Public Health. 2020 Jul 3;8:281. doi: 10.3389/fpubh.2020.00281. eCollection 2020.
Coronaviruses are enveloped positive-sense RNA viruses with an unusual large RNA genome and a unique replication mechanism, which are characterized by club-like spikes that protrude from their surface. An outbreak of a novel coronavirus 2019 infection has posed significant threat to the health and economies in the whole world. This article reviewed the viral replication, pathogenicity, prevention and treatment strategies. With a lack of approved treatment options for this virus, alternative approaches to control the spread of disease is in urgent need. This article also covers some management strategies which may be applied to this virus outbreak. Ongoing clinical studies related to possible treatments for COVID-19, potential vaccines, and alternative medication such as natural compounds are also discussed.
冠状病毒是带有不寻常大 RNA 基因组和独特复制机制的包膜正链 RNA 病毒，其表面有棒状突起的刺突。2019 年新型冠状病毒的爆发对全球健康和经济构成了重大威胁。本文综述了病毒的复制、致病性、预防和治疗策略。由于缺乏针对该病毒的批准治疗方法，因此迫切需要控制疾病传播的替代方法。本文还涵盖了一些可能适用于该病毒爆发的管理策略。此外，还讨论了与 COVID-19 可能治疗方法、潜在疫苗以及天然化合物等替代药物相关的正在进行的临床研究。
