Sharifi-Rad Javad, Rapposelli Simona, Sestito Simona, Herrera-Bravo Jesús, Arancibia-Diaz Alejandra, Salazar Luis A, Yeskaliyeva Balakyz, Beyatli Ahmet, Leyva-Gómez Gerardo, González-Contreras Carlos, Gürer Eda Sönmez, Martorell Miquel, Calina Daniela
Facultad de Medicina, Universidad del Azuay, Cuenca 14-008, Ecuador.
Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
J Pers Med. 2022 Sep 15;12(9):1515. doi: 10.3390/jpm12091515.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a tangle-shaped accumulation of beta-amyloid peptide fragments and Tau protein in brain neurons. The pathophysiological mechanism involves the presence of Aβ-amyloid peptide, Tau protein, oxidative stress, and an exacerbated neuro-inflammatory response. This review aims to offer an updated compendium of the most recent and promising advances in AD treatment through the administration of phytochemicals. The literature survey was carried out by electronic search in the following specialized databases PubMed/Medline, Embase, TRIP database, Google Scholar, Wiley, and Web of Science regarding published works that included molecular mechanisms and signaling pathways targeted by phytochemicals in various experimental models of Alzheimer's disease in vitro and in vivo. The results of the studies showed that the use of phytochemicals against AD has gained relevance due to their antioxidant, anti-neuroinflammatory, anti-amyloid, and anti-hyperphosphorylation properties of Tau protein. Some bioactive compounds from plants have been shown to have the ability to prevent and stop the progression of Alzheimer's.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征是脑神经元中β-淀粉样肽片段和 Tau 蛋白呈缠结状积聚。其病理生理机制涉及 Aβ-淀粉样肽、Tau 蛋白的存在、氧化应激以及加剧的神经炎症反应。本综述旨在通过施用植物化学物质，提供一份关于 AD 治疗最新且有前景进展的更新纲要。通过在以下专业数据库 PubMed/Medline、Embase、TRIP 数据库、谷歌学术、Wiley 和 Web of Science 中进行电子检索，对已发表的作品进行文献调查，这些作品包括植物化学物质在体外和体内各种阿尔茨海默病实验模型中所靶向的分子机制和信号通路。研究结果表明，由于植物化学物质具有抗氧化、抗神经炎症、抗淀粉样蛋白以及 Tau 蛋白抗高磷酸化特性，其在对抗 AD 方面的应用已变得愈发重要。一些植物来源的生物活性化合物已被证明具有预防和阻止阿尔茨海默病进展的能力。
