Mogheiseh Asghar, Ahmadi Mohammad Rahim, Nazifi Saeed, Mirzaei Abdollah, Fallah Eisa
Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Shiraz P.O. Box 71441-69155, Iran.
Vet Anim Sci. 2019 Aug 27;9:100067. doi: 10.1016/j.vas.2019.100067. eCollection 2020 Jun.
In this study, the fate of corpus luteum was investigated in cows affected by severe clinical endometritis. Also, concentration of IL-1β, IL-6, COX-2, adiponectin, leptin, progesterone (P4), PGFM, insulin, and IGF-1 were studied in severe clinical endometritis cows at day 30 ± 3 postpartum. Eighty-seven dairy cows affected by severe clinical endometritis were selected and their reproductive tract was examined by ultrasonography at day 30 ± 3 postpartum (first examination) and 14 days later (second examination). The majority of the cows with CL and affected by clinical endometritis at first examination had new CL 14 days later, and most of these cows were clean without any treatment (self-healing). The CL of about 28.7% of all cows with clinical endometritis at first examination persisted two weeks later and the uterus of most of them remained infected as pyometric cows. Most of the anestrous cows (83.3%) were pregnant, but only 51% of cows with new CL were pregnant at the end of next six month period. There was a significant difference in the means of lactation number, uterine lumen diameter, cervical diameter, and size of uterine horn, milk production at first examination, concentrations of insulin, COX-2, P4, IL-1β, and IL-6 among persistent CL, new CL, and anestrous cows. The pregnancy rate and the discharge score were different among persistent CL, new CL, and anestrous cows. In conclusion, CL on ovary of cows and its fate could affect recovery from severe clinical endometritis. The concentration of some metabolic hormones influenced the self-recovery of cows from clinical endometritis.
在本研究中，对患有严重临床子宫内膜炎的奶牛黄体的命运进行了调查。此外，还研究了产后30±3天的严重临床子宫内膜炎奶牛中白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）、环氧化酶-2（COX-2）、脂联素、瘦素、孕酮（P4）、孕二醇（PGFM）、胰岛素和胰岛素样生长因子-1（IGF-1）的浓度。选择了87头患有严重临床子宫内膜炎的奶牛，并在产后30±3天（首次检查）和14天后（第二次检查）通过超声检查其生殖道。首次检查时大多数有黄体且患有临床子宫内膜炎的奶牛在14天后有新的黄体形成，并且这些奶牛中的大多数未经任何治疗就恢复了（自愈）。首次检查时患有临床子宫内膜炎的所有奶牛中约28.7%的黄体在两周后仍然存在，并且其中大多数奶牛的子宫仍像积脓奶牛一样受到感染。大多数乏情奶牛（83.3%）怀孕了，但在接下来的六个月结束时，只有51%有新黄体的奶牛怀孕。在持续黄体、新黄体和乏情奶牛之间，产奶次数、子宫腔直径、宫颈直径、子宫角大小、首次检查时的产奶量、胰岛素、COX-2、P4、IL-1β和IL-6的浓度均值存在显著差异。持续黄体、新黄体和乏情奶牛之间的妊娠率和分泌物评分也有所不同。总之，奶牛卵巢上的黄体及其命运会影响严重临床子宫内膜炎的恢复。一些代谢激素的浓度会影响奶牛从临床子宫内膜炎中的自我恢复。
